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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1991-4-3
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pubmed:abstractText |
Vascular responsiveness to various vasoactive substances after exchange transfusion with a modified hemoglobin (pyridoxalated hemoglobin polyxyethylene conjugate; PHP) was examined in anesthetized rats. The hindlimb region of the rat was perfused through the abdominal aorta with autologous blood at a constant flow rate, using a perfusion pump. Perfusion pressure (PP), systemic blood pressure (SBP), and heart rate were measured. Exchange transfusion with a 6% PHP solution (20 ml/kg) was performed and effects of intra-arterial injections of norepinephrine (NE), angiotensin-II (A-II), serotonin (5-HT), acetylcholine (ACh), and nitroglycerin (NG) on PP and SBP were examined. The NE and A-II induced a dose-dependent increase in PP, while ACh and NG induced a decrease in PP. There was no difference in vascular responsiveness to ACh, NG, A-II, and 5-HT before and after exchange transfusion with PHP solution, but NE-induced responses were augmented after exchange transfusion with PHP. Results suggest that the presence of PHP moiety in circulation would not alter vascular responsiveness to ACh, NG, A-II, and 5-HT in a significant manner.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Substitutes,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/pyridoxalated-hemoglobin-polyethylen...
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0160-564X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5-14
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:1998491-Anesthesia, General,
pubmed-meshheading:1998491-Animals,
pubmed-meshheading:1998491-Blood Substitutes,
pubmed-meshheading:1998491-Hemoglobins,
pubmed-meshheading:1998491-Hindlimb,
pubmed-meshheading:1998491-Male,
pubmed-meshheading:1998491-Perfusion,
pubmed-meshheading:1998491-Polyethylene Glycols,
pubmed-meshheading:1998491-Rats,
pubmed-meshheading:1998491-Rats, Inbred Strains,
pubmed-meshheading:1998491-Vascular Resistance,
pubmed-meshheading:1998491-Vasoconstrictor Agents,
pubmed-meshheading:1998491-Vasodilator Agents
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pubmed:year |
1991
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pubmed:articleTitle |
Vascular responsiveness to various vasoactive substances after exchange transfusion with pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) solution in anesthetized rats.
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pubmed:affiliation |
Life Science Laboratories, Ajinomoto Co., Inc., Yokohama, Japan.
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pubmed:publicationType |
Journal Article
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