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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
2
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pubmed:dateCreated |
1991-4-1
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pubmed:abstractText |
Administration of dibutyltin dilaurate (DBTL; 0, 20 or 40 mg/kg body wt.) by gavage to rats for 3 consecutive days produced a significant increase in polyamine levels in selected brain areas. At the higher dose of DBTL (40 mg/kg) spermidine levels were raised in pons-medulla, hypothalamus and frontal cortex while spermine levels increased in pons-medulla, hippocampus and frontal cortex regions. At the lower dose (20 mg/kg) only a slight increase in polyamine levels occurred. The observed induction in regional brain polyamines in DBTL-treated rats may lead to disturbances in synaptic function and further enhance its neurotoxic potential.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0378-4274
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-83
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1998205-Animals,
pubmed-meshheading:1998205-Anthelmintics,
pubmed-meshheading:1998205-Body Weight,
pubmed-meshheading:1998205-Brain,
pubmed-meshheading:1998205-Female,
pubmed-meshheading:1998205-Organotin Compounds,
pubmed-meshheading:1998205-Rats,
pubmed-meshheading:1998205-Rats, Inbred Strains,
pubmed-meshheading:1998205-Spermidine,
pubmed-meshheading:1998205-Spermine
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pubmed:year |
1991
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|
pubmed:articleTitle |
Effect of dibutyltin dilaurate on regional brain polyamines in rats.
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pubmed:affiliation |
Industrial Toxicology Research Center, Lucknow, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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