Linked Life Data

1998008

Source:http://linkedlifedata.com/resource/pubmed/id/1998008

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1991-4-2
pubmed:abstractText
A breeder diet that shortens estrous cycles in mice has been reported to contain estrogenic substances, based on its ability to increase uterine weight of immature mice. However, the estrogenicity of the diet was inferred from uterine weight gain of immature mice that were intact. The increased uterine weight of mice on the breeder diet could thus have resulted from a precocious pubertal increase of endogenous estrogens induced by the diet rather than estrogenic substances in the diet. We therefore measured the estrogenicity of the breeder diet in ovariectomized animals. C57BL/6J mice were fed the breeder diet or a standard diet for 1 or 4 weeks. The breeder diet failed to increase uterine weights above control values for either treatment interval. Intact mice that were fed the breeder diet had twice the number of cycles of mice fed the standard diet, a confirmation of earlier studies. These results indicate that the breeder diet does not contain biologically significant estrogenic activity, and thus potentiates cyclicity by other means.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
196
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
321-4
pubmed:dateRevised
2007-11-2
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Absence of estrogenic activity in a diet that promotes estrous cyclicity in C57BL/6J mice.
pubmed:affiliation
Department of Physiology, University of Texas Health Science Center, San Antonio 78284-7756.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't