Linked Life Data

1997247

Source:http://linkedlifedata.com/resource/pubmed/id/1997247

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
264
pubmed:dateCreated
1991-4-4
pubmed:abstractText
To investigate the effects of diabetes and insulin treatment on trabecular bone, the morphologic and biomechanical characteristics of the femoral neck in rats with streptozotocin-induced diabetes were studied. Young Sprague-Dawley rats were divided into three groups, control, diabetic (DM), and diabetic with insulin (DI), and maintained for ten weeks. Cantilever-bending tests to failure were conducted on the proximal femur, and fracture-surface cross sections were analyzed. Morphologically, the femoral necks in diabetic rats decreased in the relative size of their cortical shell and increased their trabecular core. Structurally, the load and the energy at the proportional limit and the total energy in diabetic femoral necks were significantly less than controls. In material properties, the diabetic femoral necks had significantly less stress at the proportional limit. Compared to the DM group, the DI femoral necks had significantly greater load and energy at the proportional limit and significantly greater total energy. Femoral neck mechanical and morphologic properties in diabetic rats were significantly lower than controls, but insulin treatment ameliorated diabetic osteopathy in the rat femoral neck.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0009-921X
pubmed:author
pubmed:issnType
Print
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
278-85
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Experimental diabetes, insulin treatment, and femoral neck morphology and biomechanics in rats.
pubmed:affiliation
Department of Kinesiology, University of California Los Angeles.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't