Linked Life Data

19968467

Source:http://linkedlifedata.com/resource/pubmed/id/19968467

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-12-8
pubmed:abstractText
Planarians change in body size depending upon whether they are in feeding or starving conditions. To investigate how planarians regulate this flexible system, the numbers of total cells and specific cell types were counted and compared among worms 2 mm to 9 mm in body length. The total cell number increased linearly with increasing body length, but the ratio of cell numbers between the head and the trunk portion was constant (1:3). Interestingly, counting the numbers of specific neurons in the eye and brain after immunostaining using cell type-specific antibodies revealed that the ratio between different neuron types was constant regardless of the brain and body size. These results suggest that planarians can maintain proportionality while changing their body size by maintaining a constant ratio of different cell types. To understand this system and reveal how planarians restore the original ratio during eye and brain regeneration, the numbers of specialized cells were Investigated during regeneration. The results further substantiate the existence of some form of "counting mechanism" that has the ability to regulate both the absolute and relative numbers of different cell types in complex organs such as the brain during cell turnover, starvation, and regeneration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0289-0003
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
805-13
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Planarians maintain a constant ratio of different cell types during changes in body size by using the stem cell system.
pubmed:affiliation
Department of Biophysics, Graduate School of Science, Kyoto University, Oiwake, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't