19965812

Source:http://linkedlifedata.com/resource/pubmed/id/19965812

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0007620, umls-concept:C0034067, umls-concept:C0037083, umls-concept:C0074992, umls-concept:C0225698, umls-concept:C0679199, umls-concept:C1710082, umls-concept:C1948023
pubmed:issue	4
pubmed:dateCreated	2010-2-4
pubmed:abstractText	Vascular endothelial growth factor receptor (VEGFR) inhibition increases ceramides in lung structural cells of the alveolus, initiating apoptosis and alveolar destruction morphologically resembling emphysema. The effects of increased endogenous ceramides could be offset by sphingosine 1-phosphate (S1P), a prosurvival by-product of ceramide metabolism.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9421642
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Ceramides, http://linkedlifedata.com/resource/pubmed/chemical/Indoles, http://linkedlifedata.com/resource/pubmed/chemical/Lysophospholipids, http://linkedlifedata.com/resource/pubmed/chemical/Phosphotransferases (Alcohol Group..., http://linkedlifedata.com/resource/pubmed/chemical/Propylene Glycols, http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lysosphingolipid, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vascular Endothelial..., http://linkedlifedata.com/resource/pubmed/chemical/SU 5416, http://linkedlifedata.com/resource/pubmed/chemical/Sphingosine, http://linkedlifedata.com/resource/pubmed/chemical/fingolimod, http://linkedlifedata.com/resource/pubmed/chemical/sphingosine 1-phosphate, http://linkedlifedata.com/resource/pubmed/chemical/sphingosine kinase
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1535-4970
pubmed:author	pubmed-author:AdamowiczJeremy JJJ, pubmed-author:BerdyshevEvgeny VEV, pubmed-author:DiabKhalil JKJ, pubmed-author:GarrisonJanaJ, pubmed-author:HubbardWalter CWC, pubmed-author:KamockiKrzysztofK, pubmed-author:PetracheIrinaI, pubmed-author:RajashekharGangarajuG, pubmed-author:RushNatalia INI, pubmed-author:SchweitzerKelly SKS, pubmed-author:SkobelevaAnastasiaA, pubmed-author:YuanGuG
pubmed:issnType	Electronic
pubmed:day	15
pubmed:volume	181
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	344-52
pubmed:meshHeading	pubmed-meshheading:19965812-Animals, pubmed-meshheading:19965812-Apoptosis, pubmed-meshheading:19965812-Blotting, Western, pubmed-meshheading:19965812-Cells, Cultured, pubmed-meshheading:19965812-Ceramides, pubmed-meshheading:19965812-Disease Models, Animal, pubmed-meshheading:19965812-Dose-Response Relationship, Drug, pubmed-meshheading:19965812-Indoles, pubmed-meshheading:19965812-Lysophospholipids, pubmed-meshheading:19965812-Mice, pubmed-meshheading:19965812-Mice, Inbred C57BL, pubmed-meshheading:19965812-Phosphotransferases (Alcohol Group Acceptor), pubmed-meshheading:19965812-Polymerase Chain Reaction, pubmed-meshheading:19965812-Propylene Glycols, pubmed-meshheading:19965812-Pulmonary Alveoli, pubmed-meshheading:19965812-Pulmonary Emphysema, pubmed-meshheading:19965812-Pyrroles, pubmed-meshheading:19965812-Receptors, Lysosphingolipid, pubmed-meshheading:19965812-Receptors, Vascular Endothelial Growth Factor, pubmed-meshheading:19965812-Signal Transduction, pubmed-meshheading:19965812-Sphingosine
pubmed:year	2010
pubmed:articleTitle	Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema.
pubmed:affiliation	Division of Pulmonary, Allergy, Critical Care, and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202-5120, USA.
pubmed:publicationType	Journal Article