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rdf:type |
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lifeskim:mentions |
umls-concept:C0028630,
umls-concept:C0040715,
umls-concept:C0205147,
umls-concept:C0205164,
umls-concept:C0242647,
umls-concept:C0334634,
umls-concept:C0439682,
umls-concept:C0441587,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C1515722,
umls-concept:C1522702,
umls-concept:C1549781,
umls-concept:C2348205
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pubmed:issue |
11
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pubmed:dateCreated |
2010-3-19
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pubmed:abstractText |
The t(14;18)(q32;q21) involving the immunoglobulin heavy chain locus (IGH) and the MALT1 gene is a recurrent abnormality in mucosa-associated lymphoid tissue (MALT) lymphomas. However, the nucleotide sequence of only one t(14;18)-positive MALT lymphoma has been reported so far. We here report the molecular characterization of the IGH-MALT1 fusion products in 5 new cases of t(14;18)-positive MALT lymphomas. Similar to the IGH-associated translocations in follicular and mantle cell lymphomas, the IGH-MALT1 junctions in MALT lymphoma showed all features of a recombination signal sequence-guided V(D)J-mediated translocation at the IGH locus. Furthermore, analogous to follicular and mantle cell lymphoma, templated nucleotides (T-nucleotides) were identified at the t(14;18)/IGH-MALT1 breakpoint junctions. On chromosome 18, we identified a novel major breakpoint region in MALT1 upstream of its coding region. Moreover, the presence of duplications of MALT1 nucleotides in one case suggests an underlying staggered DNA-break process not consistent with V(D)J-mediated recombination. The molecular characteristics of the t(14;18)/IGH-MALT1 resemble those found in the t(14;18)/IGH-BCL2 in follicular lymphoma and t(11;14)/CCND1-IGH in mantle cell lymphoma, suggesting that these translocations could be generated by common pathomechanisms involving illegitimate V(D)J-mediated recombination on IGH as well as new synthesis of T-nucleotides and nonhomologous end joining (NHEJ) or alternative NHEJ repair pathways on the IGH-translocation partner.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1528-0020
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pubmed:author |
pubmed-author:Albert-KonetznyNadineN,
pubmed-author:BergerFrançoiseF,
pubmed-author:BokemeyerCarstenC,
pubmed-author:Callet-BauchuEvelyneE,
pubmed-author:DierlammJudithJ,
pubmed-author:DuMing-QingMQ,
pubmed-author:GazzoSophieS,
pubmed-author:Murga PenasEva MariaEM,
pubmed-author:SallesGillesG,
pubmed-author:SchillingGeorgiaG,
pubmed-author:VettorazziEikE,
pubmed-author:WlodarskaIwonaI,
pubmed-author:YeHongtaoH
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2214-9
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pubmed:dateRevised |
2010-4-30
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pubmed:meshHeading |
pubmed-meshheading:19965626-Aged,
pubmed-meshheading:19965626-Base Sequence,
pubmed-meshheading:19965626-Caspases,
pubmed-meshheading:19965626-Chromosome Breakpoints,
pubmed-meshheading:19965626-Chromosomes, Human, Pair 14,
pubmed-meshheading:19965626-Chromosomes, Human, Pair 18,
pubmed-meshheading:19965626-Female,
pubmed-meshheading:19965626-Genetic Loci,
pubmed-meshheading:19965626-Humans,
pubmed-meshheading:19965626-Immunoglobulin Heavy Chains,
pubmed-meshheading:19965626-Lymphoma, B-Cell, Marginal Zone,
pubmed-meshheading:19965626-Lymphoma, Follicular,
pubmed-meshheading:19965626-Lymphoma, Mantle-Cell,
pubmed-meshheading:19965626-Male,
pubmed-meshheading:19965626-Middle Aged,
pubmed-meshheading:19965626-Molecular Sequence Data,
pubmed-meshheading:19965626-Mutagenesis, Insertional,
pubmed-meshheading:19965626-Mutation,
pubmed-meshheading:19965626-Neoplasm Proteins,
pubmed-meshheading:19965626-Nucleotides,
pubmed-meshheading:19965626-Oncogene Proteins, Fusion,
pubmed-meshheading:19965626-Templates, Genetic,
pubmed-meshheading:19965626-Translocation, Genetic
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pubmed:year |
2010
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pubmed:articleTitle |
The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma.
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pubmed:affiliation |
Department of Oncology and Hematology, BMT with Section of Pneumology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. murga@uke.unihamburg.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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