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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5956
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pubmed:dateCreated |
2009-12-7
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pubmed:abstractText |
The molecular mechanisms that achieve homeostatic stabilization of neural function remain largely unknown. To better understand how neural function is stabilized during development and throughout life, we used an electrophysiology-based forward genetic screen and assessed the function of more than 250 neuronally expressed genes for a role in the homeostatic modulation of synaptic transmission in Drosophila. This screen ruled out the involvement of numerous synaptic proteins and identified a critical function for dysbindin, a gene linked to schizophrenia in humans. We found that dysbindin is required presynaptically for the retrograde, homeostatic modulation of neurotransmission, and functions in a dose-dependent manner downstream or independently of calcium influx. Thus, dysbindin is essential for adaptive neural plasticity and may link altered homeostatic signaling with a complex neurological disease.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-10864946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-11316798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-12559388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-14623361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-14735113,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-15337639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-15345706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-16166606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-16448387,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-16612196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-16776588,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-17114050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-17767166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-17961984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-18504299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-18701072,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19965435-9427247
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
20
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pubmed:volume |
326
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1127-30
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pubmed:dateRevised |
2011-7-27
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pubmed:meshHeading |
pubmed-meshheading:19965435-Animals,
pubmed-meshheading:19965435-Calcium,
pubmed-meshheading:19965435-Calcium Channels,
pubmed-meshheading:19965435-Carrier Proteins,
pubmed-meshheading:19965435-Drosophila Proteins,
pubmed-meshheading:19965435-Drosophila melanogaster,
pubmed-meshheading:19965435-Genes, Insect,
pubmed-meshheading:19965435-Glutamic Acid,
pubmed-meshheading:19965435-Homeostasis,
pubmed-meshheading:19965435-Humans,
pubmed-meshheading:19965435-Mutation,
pubmed-meshheading:19965435-Neuromuscular Junction,
pubmed-meshheading:19965435-Neuronal Plasticity,
pubmed-meshheading:19965435-Schizophrenia,
pubmed-meshheading:19965435-Synapses,
pubmed-meshheading:19965435-Synaptic Transmission,
pubmed-meshheading:19965435-Synaptic Vesicles,
pubmed-meshheading:19965435-Transgenes
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pubmed:year |
2009
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pubmed:articleTitle |
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis.
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pubmed:affiliation |
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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