| pubmed-article:1996351 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1996351 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:1996351 | lifeskim:mentions | umls-concept:C0812319 | lld:lifeskim |
| pubmed-article:1996351 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:1996351 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:1996351 | lifeskim:mentions | umls-concept:C1523298 | lld:lifeskim |
| pubmed-article:1996351 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:1996351 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1996351 | pubmed:dateCreated | 1991-3-27 | lld:pubmed |
| pubmed-article:1996351 | pubmed:abstractText | During early cardiac development, the progenitor cells of the heart valves and membranous septa undergo an epithelial-mesenchymal transformation. Previous studies have shown that this transformation depends on the activity of a transforming growth factor beta (TGF beta) molecule produced by the heart. In the present study, we have used modified antisense oligodeoxynucleotides generated to nonconserved regions of TGF beta 1, -2, -3, and -4 to examine the possible roles of these members in this transformation. A phosphoramidate-modified oligonucleotide complementary to TGF beta 3 mRNA was capable of inhibiting normal epithelial-mesenchymal transformation by 80%. Unmodified oligonucleotides to TGF beta 3, modified oligonucleotides to TGF beta 1, -2, and -4, and two modified control oligonucleotides were unable to inhibit the transformation. These data demonstrate that a specific member of the TGF beta family, TGF beta 3, is essential for the epithelial-mesenchymal cell transformation. | lld:pubmed |
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| pubmed-article:1996351 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1996351 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1996351 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1996351 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1996351 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1996351 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1996351 | pubmed:author | pubmed-author:WalderJ AJA | lld:pubmed |
| pubmed-article:1996351 | pubmed:author | pubmed-author:RunyanR BRB | lld:pubmed |
| pubmed-article:1996351 | pubmed:author | pubmed-author:WeeksD LDL | lld:pubmed |
| pubmed-article:1996351 | pubmed:author | pubmed-author:PottsJ DJD | lld:pubmed |
| pubmed-article:1996351 | pubmed:author | pubmed-author:DagleJ MJM | lld:pubmed |
| pubmed-article:1996351 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1996351 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1996351 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:1996351 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1996351 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1996351 | pubmed:pagination | 1516-20 | lld:pubmed |
| pubmed-article:1996351 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1996351 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1996351 | pubmed:articleTitle | Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor beta 3. | lld:pubmed |
| pubmed-article:1996351 | pubmed:affiliation | Department of Anatomy, University of Iowa, Iowa City 52242. | lld:pubmed |
| pubmed-article:1996351 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1996351 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1996351 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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