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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-3
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pubmed:abstractText |
As a part of our program to develop new antifungal agents, a series of fluconazole analogues was designed and synthesized wherein one of the triazole moieties in fluconazole was replaced with 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moiety. The new chemical entities thus synthesized were screened against various fungi and it was observed that the compounds 4a and 4i are potent inhibitors of Candida strains. The structure-activity relationship for these compounds is discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:BorateHanumant BHB,
pubmed-author:ChandavarkarMohan AMA,
pubmed-author:ChavanSubhash PSP,
pubmed-author:IyerRamkiR,
pubmed-author:JoshiVinay AVA,
pubmed-author:KelkarRamesh GRG,
pubmed-author:KunteSunita SSS,
pubmed-author:MaujanSuleman RSR,
pubmed-author:SawargaveSangmeshwer PSP,
pubmed-author:VaiudeSharangi RSR,
pubmed-author:WakharkarRadhika DRD
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pubmed:copyrightInfo |
Copyright 2009 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
722-5
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pubmed:meshHeading |
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pubmed:year |
2010
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pubmed:articleTitle |
Fluconazole analogues containing 2H-1,4-benzothiazin-3(4H)-one or 2H-1,4-benzoxazin-3(4H)-one moieties, a novel class of anti-Candida agents.
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pubmed:affiliation |
Division of Organic Chemistry, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India. hb.borate@ncl.res.in
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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