| pubmed-article:19963284 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19963284 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19963284 | lifeskim:mentions | umls-concept:C2911696 | lld:lifeskim |
| pubmed-article:19963284 | lifeskim:mentions | umls-concept:C0360105 | lld:lifeskim |
| pubmed-article:19963284 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19963284 | pubmed:dateCreated | 2010-2-1 | lld:pubmed |
| pubmed-article:19963284 | pubmed:abstractText | Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for the treatment of depression and anxiety-related disorders. These drugs target the serotonin transporter (5-HTT) and increase serotonin signalling. Although chronic SSRI administration has few reported side effects, recent observations suggest that it could have long-term effects on neurodevelopment. First, 5-HTT is transiently expressed in many brain areas during development. Second, 5-HTT blockade during development causes wiring defects in these areas. These effects are seen most clearly in the sensory systems. Third, the behavioural effects of 5-HTT blockade during development are sometimes dramatically different from the effects of 5-HTT blockade during adulthood. Most of this evidence was collected from studies with 5-HTT knockout mice and rats. However, the phenotypes associated with low or high functioning 5-HTT alleles in humans can result from similar developmental alterations in 5-HT levels. Here, we review the existing evidence on the long-term effects of developmental SSRI exposure. | lld:pubmed |
| pubmed-article:19963284 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19963284 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19963284 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19963284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19963284 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19963284 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19963284 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19963284 | pubmed:issn | 1873-3735 | lld:pubmed |
| pubmed-article:19963284 | pubmed:author | pubmed-author:GasparPatrici... | lld:pubmed |
| pubmed-article:19963284 | pubmed:author | pubmed-author:HombergJudith... | lld:pubmed |
| pubmed-article:19963284 | pubmed:author | pubmed-author:SchubertDirkD | lld:pubmed |
| pubmed-article:19963284 | pubmed:copyrightInfo | Copyright 2009 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:19963284 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19963284 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:19963284 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19963284 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19963284 | pubmed:pagination | 60-5 | lld:pubmed |
| pubmed-article:19963284 | pubmed:meshHeading | pubmed-meshheading:19963284... | lld:pubmed |
| pubmed-article:19963284 | pubmed:meshHeading | pubmed-meshheading:19963284... | lld:pubmed |
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| pubmed-article:19963284 | pubmed:meshHeading | pubmed-meshheading:19963284... | lld:pubmed |
| pubmed-article:19963284 | pubmed:meshHeading | pubmed-meshheading:19963284... | lld:pubmed |
| pubmed-article:19963284 | pubmed:meshHeading | pubmed-meshheading:19963284... | lld:pubmed |
| pubmed-article:19963284 | pubmed:meshHeading | pubmed-meshheading:19963284... | lld:pubmed |
| pubmed-article:19963284 | pubmed:meshHeading | pubmed-meshheading:19963284... | lld:pubmed |
| pubmed-article:19963284 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19963284 | pubmed:articleTitle | New perspectives on the neurodevelopmental effects of SSRIs. | lld:pubmed |
| pubmed-article:19963284 | pubmed:affiliation | Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Centre, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands. j.homberg@cns.umcn.n | lld:pubmed |
| pubmed-article:19963284 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19963284 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19963284 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19963284 | lld:pubmed |
