Linked Life Data

19963006

Source:http://linkedlifedata.com/resource/pubmed/id/19963006

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-8-23
pubmed:abstractText
Individual differences in the cardiovascular response to stress play a central role in the reactivity hypothesis linking frequent exposure to psychosocial stress to adverse outcomes in cardiovascular health. To assess the importance of genetic factors, a meta-analysis was performed on all published twin studies that assessed heart rate (HR) or blood pressure (BP) reactivity to the cold pressor test or various mental stress tasks. For reactivity to mental stress, the pooled heritability estimate ranged from 0.26 to 0.43. Reactivity to the cold pressor test yielded heritability estimates from 0.21 to 0.55. An ensuing review of genetic association studies revealed a number of genes, mostly within the sympathoadrenal pathway, that may account for part of the heritability of cardiovascular stress reactivity. Future progress in gene finding, that should include measures of sympathetic and vagal stress reactivity, may help uncover the molecular pathways from genetic variation to stress reactivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1873-7528
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
58-68
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Genetic influences on cardiovascular stress reactivity.
pubmed:affiliation
Unit of Genetic Epidemiology and Bioinformatics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
pubmed:publicationType
Journal Article, Review, Meta-Analysis