| pubmed-article:19961871 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19961871 | lifeskim:mentions | umls-concept:C0036108 | lld:lifeskim |
| pubmed-article:19961871 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:19961871 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:19961871 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19961871 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:19961871 | lifeskim:mentions | umls-concept:C0443264 | lld:lifeskim |
| pubmed-article:19961871 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:19961871 | pubmed:dateCreated | 2010-2-17 | lld:pubmed |
| pubmed-article:19961871 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19961871 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19961871 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19961871 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19961871 | pubmed:abstractText | Interleukin (IL)-17 family members (IL-17A-F) are key players in adaptive immune responses and have a central role in coordinating innate and adaptive immunity. Here, we report on two novel IL-17 homologues in rainbow trout Oncorhynchus mykiss, trout (t) IL-17C1 and tIL-17C2, that share 73.7% amino acid identity. The two tIL-17C-like molecules have relatively higher sequence identities to IL-17Cs from fish and mammals and the fish IL-17C-like molecules phylogenetically form a specific clade that groups with the mammalian IL-17C and IL-17E clades. However, the gene organisation of the fish IL-17C-like molecules is closer to mammalian IL-17Es than to IL-17Cs, and this taken together with other factors suggest the fish IL-17C-like genes may have arisen from an ancestral gene that gave rise to mammalian IL-17C and IL-17E. The expression of tIL-17Cs was detectable in all the eight tissues examined, with the expression of tIL-17 mainly contributed by tIL-17C1 in gills and skin, and by tIL-17C2 in spleen, head kidney and brain. The expression of tIL-17Cs was modulated by inflammatory stimulants, including IL-1beta, interferon-gamma, LPS and PolyIC, in a trout macrophage cell line (RTS-11). IL-1beta was the most potent inducer of tIL-17C2 but only had a minor effect on the expression of tIL-17C1. LPS and PolyIC were also potent inducers of tIL-17C2. The expression of tIL-17Cs was also up-regulated by bacterial infection, with the extent and increase more dramatic for tIL-17C2. The broad distribution of expression and differential modulation of tIL-17Cs by inflammatory stimulants and infection suggest important roles of the two tIL-17Cs in the salmonid immune system. | lld:pubmed |
| pubmed-article:19961871 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19961871 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19961871 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19961871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19961871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19961871 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19961871 | pubmed:month | May | lld:pubmed |
| pubmed-article:19961871 | pubmed:issn | 1879-0089 | lld:pubmed |
| pubmed-article:19961871 | pubmed:author | pubmed-author:SecombesChris... | lld:pubmed |
| pubmed-article:19961871 | pubmed:author | pubmed-author:WangTiehuiT | lld:pubmed |
| pubmed-article:19961871 | pubmed:author | pubmed-author:MartinSamuel... | lld:pubmed |
| pubmed-article:19961871 | pubmed:copyrightInfo | Copyright (c) 2009 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:19961871 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19961871 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:19961871 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19961871 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19961871 | pubmed:pagination | 491-500 | lld:pubmed |
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| pubmed-article:19961871 | pubmed:meshHeading | pubmed-meshheading:19961871... | lld:pubmed |
| pubmed-article:19961871 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19961871 | pubmed:articleTitle | Two interleukin-17C-like genes exist in rainbow trout Oncorhynchus mykiss that are differentially expressed and modulated. | lld:pubmed |
| pubmed-article:19961871 | pubmed:affiliation | Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK. | lld:pubmed |
| pubmed-article:19961871 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19961871 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:100462681 | entrezgene:pubmed | pubmed-article:19961871 | lld:entrezgene |
| entrez-gene:100462682 | entrezgene:pubmed | pubmed-article:19961871 | lld:entrezgene |
