Source:http://linkedlifedata.com/resource/pubmed/id/19961871
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2010-2-17
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| pubmed:databankReference | |
| pubmed:abstractText |
Interleukin (IL)-17 family members (IL-17A-F) are key players in adaptive immune responses and have a central role in coordinating innate and adaptive immunity. Here, we report on two novel IL-17 homologues in rainbow trout Oncorhynchus mykiss, trout (t) IL-17C1 and tIL-17C2, that share 73.7% amino acid identity. The two tIL-17C-like molecules have relatively higher sequence identities to IL-17Cs from fish and mammals and the fish IL-17C-like molecules phylogenetically form a specific clade that groups with the mammalian IL-17C and IL-17E clades. However, the gene organisation of the fish IL-17C-like molecules is closer to mammalian IL-17Es than to IL-17Cs, and this taken together with other factors suggest the fish IL-17C-like genes may have arisen from an ancestral gene that gave rise to mammalian IL-17C and IL-17E. The expression of tIL-17Cs was detectable in all the eight tissues examined, with the expression of tIL-17 mainly contributed by tIL-17C1 in gills and skin, and by tIL-17C2 in spleen, head kidney and brain. The expression of tIL-17Cs was modulated by inflammatory stimulants, including IL-1beta, interferon-gamma, LPS and PolyIC, in a trout macrophage cell line (RTS-11). IL-1beta was the most potent inducer of tIL-17C2 but only had a minor effect on the expression of tIL-17C1. LPS and PolyIC were also potent inducers of tIL-17C2. The expression of tIL-17Cs was also up-regulated by bacterial infection, with the extent and increase more dramatic for tIL-17C2. The broad distribution of expression and differential modulation of tIL-17Cs by inflammatory stimulants and infection suggest important roles of the two tIL-17Cs in the salmonid immune system.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
1879-0089
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
34
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
491-500
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| pubmed:meshHeading |
pubmed-meshheading:19961871-Adaptive Immunity,
pubmed-meshheading:19961871-Amino Acid Sequence,
pubmed-meshheading:19961871-Animals,
pubmed-meshheading:19961871-Bacterial Infections,
pubmed-meshheading:19961871-Cell Line,
pubmed-meshheading:19961871-Evolution, Molecular,
pubmed-meshheading:19961871-Gene Duplication,
pubmed-meshheading:19961871-Gene Expression Profiling,
pubmed-meshheading:19961871-Gene Expression Regulation,
pubmed-meshheading:19961871-Gills,
pubmed-meshheading:19961871-Inflammation Mediators,
pubmed-meshheading:19961871-Interleukin-17,
pubmed-meshheading:19961871-Macrophages,
pubmed-meshheading:19961871-Mammals,
pubmed-meshheading:19961871-Molecular Sequence Data,
pubmed-meshheading:19961871-Oncorhynchus mykiss,
pubmed-meshheading:19961871-Organ Specificity,
pubmed-meshheading:19961871-Sequence Alignment,
pubmed-meshheading:19961871-Sequence Homology, Amino Acid,
pubmed-meshheading:19961871-Skin
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| pubmed:year |
2010
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| pubmed:articleTitle |
Two interleukin-17C-like genes exist in rainbow trout Oncorhynchus mykiss that are differentially expressed and modulated.
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| pubmed:affiliation |
Scottish Fish Immunology Research Centre, School of Biological Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, UK.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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