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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-12-21
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pubmed:abstractText |
The integrase (IN) of human immunodeficiency virus type 1 (HIV-1) has been implicated in different steps during viral replication, including nuclear import of the viral pre-integration complex. The exact mechanisms underlying the nuclear import of IN and especially the question of whether it bears a functional nuclear localization signal (NLS) remain controversial.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1742-4690
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112
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pubmed:meshHeading |
pubmed-meshheading:19961612-Active Transport, Cell Nucleus,
pubmed-meshheading:19961612-Animals,
pubmed-meshheading:19961612-COS Cells,
pubmed-meshheading:19961612-Cell Nucleus,
pubmed-meshheading:19961612-Cercopithecus aethiops,
pubmed-meshheading:19961612-HIV Infections,
pubmed-meshheading:19961612-HIV Integrase,
pubmed-meshheading:19961612-HIV Integrase Inhibitors,
pubmed-meshheading:19961612-HIV-1,
pubmed-meshheading:19961612-HeLa Cells,
pubmed-meshheading:19961612-Host-Pathogen Interactions,
pubmed-meshheading:19961612-Humans,
pubmed-meshheading:19961612-Metabolic Networks and Pathways,
pubmed-meshheading:19961612-Nuclear Localization Signals,
pubmed-meshheading:19961612-Virus Integration,
pubmed-meshheading:19961612-Virus Replication,
pubmed-meshheading:19961612-alpha Karyopherins
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pubmed:year |
2009
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pubmed:articleTitle |
Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal.
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pubmed:affiliation |
Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel. aviadl@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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