Source:http://linkedlifedata.com/resource/pubmed/id/19960418
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2010-6-3
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| pubmed:abstractText |
On Jeju Island, South Korea, the leaves of Eurya emarginata have been traditionally used to treat ulcers or as a diuretic. Eutigoside C isolated from the leaves has been reported to have in vitro anti-inflammatory effects. We evaluated the radioprotective effects of eutigoside C on jejunal cell apoptosis and crypt survival in mice subjected to gamma irradiation. In addition, the ability of eutigoside C to protect against radiation-induced oxidative stress was examined by evaluating the activities of superoxide dismutase (SOD) and catalase (CAT) in radiation-induced hepatic injury. Eutigoside C was administered intraperitoneally at 48, 12, and 1 h before irradiation. The administration of eutigoside C (10, 50, or 100 mg/kg body weight) before irradiation protected the intestinal crypts from radiation-induced apoptosis (p < 0.05), and attenuated radiation-induced decrease of villous height (p < 0.05). Pretreating mice prior to irradiation with eutigoside C (100 mg/kg) significantly improved the survival of the jejunal crypt (p < 0.01). The dose reduction factor was 1.09 at 3.5 days after irradiation. Treatment of eutigoside C prior to irradiation significantly protected SOD and CAT activities in radiation-induced hepatic injury (p < 0.05). These results suggest that eutigoside C is a useful radioprotector capable of defending intestinal progenitor cells against indirect depletion, such as oxidative stress and inflammatory response caused by gamma irradiation.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catalase,
http://linkedlifedata.com/resource/pubmed/chemical/Glucosides,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/Radiation-Protective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/eutigoside C
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
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| pubmed:issn |
1099-1573
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| pubmed:author |
pubmed-author:AhnKyuyoungK,
pubmed-author:HyunJin WonJW,
pubmed-author:JeeYoungheunY,
pubmed-author:KimJeongtaeJ,
pubmed-author:KimJihoonJ,
pubmed-author:KimSung-HoSH,
pubmed-author:LeeNam HoNH,
pubmed-author:MoonChangjongC,
pubmed-author:OhTae HeonTH,
pubmed-author:ParkJae WooJW,
pubmed-author:ShinTaekyunT
|
| pubmed:copyrightInfo |
(c) 2009 John Wiley & Sons, Ltd.
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
24
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
840-5
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| pubmed:meshHeading |
pubmed-meshheading:19960418-Angiosperms,
pubmed-meshheading:19960418-Animals,
pubmed-meshheading:19960418-Apoptosis,
pubmed-meshheading:19960418-Catalase,
pubmed-meshheading:19960418-Gamma Rays,
pubmed-meshheading:19960418-Glucosides,
pubmed-meshheading:19960418-Intestines,
pubmed-meshheading:19960418-Jejunum,
pubmed-meshheading:19960418-Male,
pubmed-meshheading:19960418-Mice,
pubmed-meshheading:19960418-Mice, Inbred BALB C,
pubmed-meshheading:19960418-Mice, Inbred ICR,
pubmed-meshheading:19960418-Oxidative Stress,
pubmed-meshheading:19960418-Phenols,
pubmed-meshheading:19960418-Phytotherapy,
pubmed-meshheading:19960418-Radiation Injuries, Experimental,
pubmed-meshheading:19960418-Radiation-Protective Agents,
pubmed-meshheading:19960418-Superoxide Dismutase
|
| pubmed:year |
2010
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| pubmed:articleTitle |
Eutigoside C attenuates radiation-induced crypt injury in the mouse intestine.
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| pubmed:affiliation |
Department of Veterinary Anatomy, College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju, South Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|