Linked Life Data

19960292

Source:http://linkedlifedata.com/resource/pubmed/id/19960292

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-12-4
pubmed:abstractText
The clinical appearance of patients with cleidocranial dysplasia (CCD), which is caused by mutations in the RUNX2 gene, is characterized by anomalies of the clavicles, thorax, spine, pelvis and extremities and by disturbances of the skull and tooth development. Of orthodontic relevance are multiple supernumerary teeth associated with delayed tooth eruption. The present investigation is based on the hypothesis that an altered phenotypic expression of periodontal ligament (PDL) cells from CCD patients and a reduced ability of those cells to support the differentiation of bone-resorbing osteoclasts might contribute to delayed tooth eruption.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1615-6714
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
495-510
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The role of periodontal ligament cells in delayed tooth eruption in patients with cleidocranial dysostosis.
pubmed:affiliation
Department of Orthodontics, University of Bonn, Germany. s.lossdoerfer@gmx.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't