Linked Life Data

19958770

Source:http://linkedlifedata.com/resource/pubmed/id/19958770

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-1-27
pubmed:abstractText
The hepatitis B viral X protein (HBx) is a multifunctional protein that plays a role in the activation of the NF-kappaB signaling pathway. In this study, we demonstrate that HBx up-regulates expression of TANK-binding kinase-1 (TBK1) at the transcriptional level. Increased levels of TBK1 protein then induce the phosphorylation of NF-kappaB p65 at serine 536. Because TBK1 is up-regulated by HBx as part of its promotion of NF-kappaB activation, it is possible that increased TBK1 levels play a role in the development of hepatocellular carcinoma (HCC). From these data, we suggest that TBK1 may play a role in the HBx-mediated activation of the NF-kappaB signaling pathway and the development of HCCs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1873-3468
pubmed:author
pubmed:copyrightInfo
2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
5
pubmed:volume
584
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
525-30
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The hepatitis B viral X protein activates NF-kappaB signaling pathway through the up-regulation of TBK1.
pubmed:affiliation
The Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't