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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-2-12
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pubmed:abstractText |
Molecular imaging studies with benzamide radioligands can reveal competition from endogenous binding at D(2/3)-receptors in living brain. However, single photon emission computed tomography (SPECT) methods suffer from limited spatial resolution, and [(11)C]-labeled ligands are only available at positron emission tomography (PET) research sites with cyclotron-radiochemistry facilities, whereas [(18)F] can be transported, due to its longer physical half-life. Therefore, we endeavored to characterize the vulnerabilities of the benzamide antagonist [(18)F]desmethoxyfallypride (DMFP) and its high-affinity congener [(18)F]fallypride (FP) to competition from endogenous dopamine in living mouse brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1098-2396
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pubmed:author |
pubmed-author:BöningGuidoG,
pubmed-author:BartensteinPeterP,
pubmed-author:BrucheArianeA,
pubmed-author:CummingPaulP,
pubmed-author:EsmaeilzadehMounaM,
pubmed-author:GildehausFranz-JosefFJ,
pubmed-author:MilleErikE,
pubmed-author:NowakSebastianS,
pubmed-author:RomingerAxelA,
pubmed-author:TatschKlausK,
pubmed-author:WänglerBjörnB,
pubmed-author:WagnerErikaE
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pubmed:issnType |
Electronic
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
313-22
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pubmed:meshHeading |
pubmed-meshheading:19957365-Amphetamine,
pubmed-meshheading:19957365-Analysis of Variance,
pubmed-meshheading:19957365-Animals,
pubmed-meshheading:19957365-Binding, Competitive,
pubmed-meshheading:19957365-Brain,
pubmed-meshheading:19957365-Brain Mapping,
pubmed-meshheading:19957365-Dopamine,
pubmed-meshheading:19957365-Dopamine Agents,
pubmed-meshheading:19957365-Dose-Response Relationship, Drug,
pubmed-meshheading:19957365-Female,
pubmed-meshheading:19957365-Fluorine Radioisotopes,
pubmed-meshheading:19957365-Mice,
pubmed-meshheading:19957365-Mice, Inbred BALB C,
pubmed-meshheading:19957365-Positron-Emission Tomography,
pubmed-meshheading:19957365-Pyrrolidines,
pubmed-meshheading:19957365-Receptors, Dopamine D2,
pubmed-meshheading:19957365-Salicylamides,
pubmed-meshheading:19957365-Time Factors,
pubmed-meshheading:19957365-Tissue Distribution,
pubmed-meshheading:19957365-Wakefulness
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pubmed:year |
2010
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pubmed:articleTitle |
Endogenous competition against binding of [(18)F]DMFP and [(18)F]fallypride to dopamine D(2/3) receptors in brain of living mouse.
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pubmed:affiliation |
Department of Nuclear Medicine, Ludwig-Maximilian University, Munich, Germany. axel.rominger@med.uni-muenchen.de
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pubmed:publicationType |
Journal Article
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