Source:http://linkedlifedata.com/resource/pubmed/id/19957188
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2010-9-16
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| pubmed:abstractText |
Serotonin (5-HT) pathways play an important role in the pathophysiology of anorexia nervosa (AN). In this study, we investigated functional characteristics of the platelet 5-HT transporter and platelet 5-HT content in AN patients at various stages of their illness in comparison to healthy control woman (HCW) controlling for the 5-HTTLPR deletion/insertion polymorphism and other confounding variables. Fasting blood samples of 58 acutely underweight AN patients (acAN, BMI = 15.2 ± 1.4), 26 AN patients of the initial acAN sample after short-term/partial weight restoration (BMI = 17.3 ± 0.9), 36 weight-recovered AN patients (recAN, BMI = 20.7 ± 2.2) and 58 HCW (BMI = 21.6 ± 2.0) were assessed for kinetic characteristics of platelet 5-HT uptake (V (max), K (m)) and platelet 5-HT content. Plasma leptin served as an indicator of malnutrition. Mean V (max) and K (m) values were significantly higher in recAN subjects in comparison to HCW (2.05 ± 0.62 vs. 1.66 ± 0.40 nmol 5-HT/10(9) platelets min and 432 ± 215 vs. 315 ± 136 nmol, respectively) but there were no differences in platelet 5-HT content (464.8 ± 210.6 vs. 472.0 ± 162.2 ng 5-HT/10(9) platelets). 5-HT parameters in acAN patients and HCW were similar. 5-HTTLPR variants were not related to 5-HT platelet variables. In the longitudinal part of the study we found significantly increased 5-HT content but unchanged 5-HT uptake in AN patients after short-term/partial weight restoration. Our results highlight the importance of malnutrition for the interpretation of abnormalities in neurotransmitter systems in AN. Changes in platelet 5-HT transporter activity were related to the stage of the illness but not to 5-HTTLPR genotype. Increased V (max) and K (m) in recovered AN patients might mirror adaptive modulations of the 5-HT system.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/SLC6A4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Plasma Membrane...
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1433-8491
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
260
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
483-90
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| pubmed:meshHeading |
pubmed-meshheading:19957188-Adolescent,
pubmed-meshheading:19957188-Adult,
pubmed-meshheading:19957188-Anorexia Nervosa,
pubmed-meshheading:19957188-Biological Markers,
pubmed-meshheading:19957188-Blood Platelets,
pubmed-meshheading:19957188-Feeding Behavior,
pubmed-meshheading:19957188-Female,
pubmed-meshheading:19957188-Genome-Wide Association Study,
pubmed-meshheading:19957188-Humans,
pubmed-meshheading:19957188-INDEL Mutation,
pubmed-meshheading:19957188-Leptin,
pubmed-meshheading:19957188-Malnutrition,
pubmed-meshheading:19957188-Polymorphism, Genetic,
pubmed-meshheading:19957188-Serotonin,
pubmed-meshheading:19957188-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:19957188-Severity of Illness Index,
pubmed-meshheading:19957188-Thinness,
pubmed-meshheading:19957188-Young Adult
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| pubmed:year |
2010
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| pubmed:articleTitle |
The 5-HTTLPR polymorphism, platelet serotonin transporter activity and platelet serotonin content in underweight and weight-recovered females with anorexia nervosa.
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| pubmed:affiliation |
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité, Universitätsmedizin Berlin, CVK, Berlin, Germany. stefan@nmr.mgh.harvard.edu
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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