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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-2-11
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pubmed:abstractText |
Endothelial activation has emerged as an early event in the pathogenesis of microcirculatory dysfunction, capillary leakage and multi-organ dysfunction syndrome (MODS). Angiopoietin-2 (Ang-2), a circulating antagonistic ligand of the endothelial-specific Tie2 receptor, has been identified as a non-redundant gatekeeper of endothelial activation. On the basis of our previous report demonstrating release of Ang-2 in endotoxemia and sepsis, we aimed to study the utility of Ang-2 to serve as an outcome-specific biomarker in patients requiring renal replacement therapy (RRT) in the intensive care unit (ICU).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1432-1238
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
462-70
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19956923-Acute Kidney Injury,
pubmed-meshheading:19956923-Adult,
pubmed-meshheading:19956923-Aged,
pubmed-meshheading:19956923-Angiopoietin-2,
pubmed-meshheading:19956923-Biological Markers,
pubmed-meshheading:19956923-Female,
pubmed-meshheading:19956923-Germany,
pubmed-meshheading:19956923-Hospital Mortality,
pubmed-meshheading:19956923-Humans,
pubmed-meshheading:19956923-Intensive Care Units,
pubmed-meshheading:19956923-Length of Stay,
pubmed-meshheading:19956923-Male,
pubmed-meshheading:19956923-Middle Aged,
pubmed-meshheading:19956923-Multiple Organ Failure,
pubmed-meshheading:19956923-Outcome Assessment (Health Care),
pubmed-meshheading:19956923-Proportional Hazards Models,
pubmed-meshheading:19956923-ROC Curve,
pubmed-meshheading:19956923-Renal Replacement Therapy
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pubmed:year |
2010
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pubmed:articleTitle |
Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome.
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pubmed:affiliation |
Department of Nephrology and Hypertension, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany. kuempers.philipp@mh-hannover.de
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pubmed:publicationType |
Journal Article
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