Linked Life Data

1995607

Source:http://linkedlifedata.com/resource/pubmed/id/1995607

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1991-3-27
pubmed:abstractText
Insulin action on gene expression can be glucose-dependent or -independent. Accumulation of aldolase B mRNA and of an unidentified 5.4-kilobase mRNA as well as accumulation of L-type pyruvate kinase mRNAs (Decaux, J.F., Antoine, B., and Kahn, A. (1989) J. Biol. Chem. 264, 11584-11590) in cultured hepatocytes isolated from fasted rats require the presence of both glucose and insulin, these agents not being effective individually. In contrast, maintaining the amount of albumin and transferrin mRNAs in these hepatocytes requires the presence of insulin alone, glucose having no effect by itself. Transcription of the albumin gene, investigated by run-on assay, is active in the presence of insulin alone, with or without glucose, whereas transcription of the aldolase B gene is stimulated by glucose and insulin together, but not by insulin or glucose alone. In addition, the stability of the albumin and aldolase B mRNAs in cultured hepatocytes is lowered in the absence of glucose and insulin together as compared to the stability in the presence of one or both agents. These results confirm that transduction of the insulin signal occurs via distinct pathways; one of these pathways could involve a secondary insulin-dependent modification of metabolite concentration, whereas other pathways could be more directly related to the activity(ies) of the occupied insulin receptor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
266
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3432-8
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Glucose-dependent and -independent effect of insulin on gene expression.
pubmed:affiliation
ICGM, Unité de Recherches en Génétique et Pathologie Molécularies, Institut National de la Santé, Recherche Médical, U 129, Paris, France.
pubmed:publicationType
Journal Article