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pubmed-article:19954977pubmed:abstractTextFor the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed.lld:pubmed
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pubmed-article:19954977pubmed:copyrightInfoCopyright 2009 Elsevier Ltd. All rights reserved.lld:pubmed
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pubmed-article:19954977pubmed:articleTitle2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study.lld:pubmed
pubmed-article:19954977pubmed:affiliationCollege of Pharmacy, Yeungnam University, Kyongsan 712-749, Republic of Korea.lld:pubmed
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