rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
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pubmed:dateCreated |
2010-2-3
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pubmed:abstractText |
For the development of novel antitumor agents, 2,6-dithienyl-4-furyl pyridine derivatives were prepared and evaluated for their topoisomerase I and II inhibitory activity as well as cytotoxicity against several human cancer cell lines. Among the 21 prepared compounds, compound 24 exhibited strong topoisomerase I inhibitory activity. In addition, a docking study with topoisomerase I and compound 24 was performed.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
1464-3405
|
pubmed:author |
pubmed-author:BasnetArjunA,
pubmed-author:ChoWon-JeaWJ,
pubmed-author:ChoiHoyoungH,
pubmed-author:ChoiJae HunJH,
pubmed-author:JahngYurngdongY,
pubmed-author:JeongByeong-SeonBS,
pubmed-author:KarkiRadhaR,
pubmed-author:KwonYoungjooY,
pubmed-author:LeeChong-SoonCS,
pubmed-author:LeeEung-SeokES,
pubmed-author:NaYounghwaY,
pubmed-author:ThapaPritamP,
pubmed-author:YunMinhoM
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pubmed:copyrightInfo |
Copyright 2009 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
1
|
pubmed:volume |
20
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
42-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19954977-Antineoplastic Agents,
pubmed-meshheading:19954977-Binding Sites,
pubmed-meshheading:19954977-Cell Line, Tumor,
pubmed-meshheading:19954977-Computer Simulation,
pubmed-meshheading:19954977-DNA Topoisomerases, Type I,
pubmed-meshheading:19954977-DNA Topoisomerases, Type II,
pubmed-meshheading:19954977-Drug Screening Assays, Antitumor,
pubmed-meshheading:19954977-Humans,
pubmed-meshheading:19954977-Pyridines,
pubmed-meshheading:19954977-Structure-Activity Relationship,
pubmed-meshheading:19954977-Thiophenes,
pubmed-meshheading:19954977-Topoisomerase I Inhibitors,
pubmed-meshheading:19954977-Topoisomerase II Inhibitors
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pubmed:year |
2010
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pubmed:articleTitle |
2,6-Dithienyl-4-furyl pyridines: Synthesis, topoisomerase I and II inhibition, cytotoxicity, structure-activity relationship, and docking study.
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pubmed:affiliation |
College of Pharmacy, Yeungnam University, Kyongsan 712-749, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|