Linked Life Data

19954080

Source:http://linkedlifedata.com/resource/pubmed/id/19954080

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-12-3
pubmed:abstractText
The highly polymorphic enzyme cytochrome P450 2D6 metabolizes about 20% of all drugs, including many antidepressants and antipsychotics. Individuals with mutant CYP2D6 alleles may be at increased risk for adverse drug reactions. We genotyped the CYP2D6 locus in 45 Puerto Rican psychiatry patients who had reported intolerance to antidepressants and/or antipsychotics. Three quarters of the group had at least one mutant allele. Twenty-one percent of the alleles had reduced activity, and eighteen percent were inactive. Two patients could not be genotyped by the microassay. Elevated basal metabolic index was common, except among patients who were homozygous extensive metabolizers. Compared to other populations that have been amply studied, Puerto Ricans may have relatively fewer inactive alleles and relatively more reduced-activity alleles.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0004-4849
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-12
pubmed:meshHeading
pubmed:articleTitle
CYP2D6 genotypes in Puerto Rican psychiatry patients with intolerance of antidepressants and antipsychotics.
pubmed:affiliation
Department of Psychiatry, University of Puerto Rico School of Medicine.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural