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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-3-28
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pubmed:abstractText |
We investigated the characteristics of the antiplatelet autoantibodies in 60 patients with ITP. Using flow cytometry, the binding of monoclonal antibodies to the platelet glycoprotein (GP) IIb/IIIa complex and to GPIb was examined in these patients. The extent of binding was decreased in 15 patients (anti-GPIIb/IIIa in 12 patients and both anti-GPIIb/IIIa and anti-GPIb in 3 patients). Western blotting revealed that 10 of these 15 patients had either anti-GPIIb or anti-GPIIIa and 2 had anti-GPIb autoantibodies, ADP-induced aggregation of normal platelets was inhibited by autoantibodies in 12 of 60 patients, and 11 of these had anti-GPIIb/IIIa antibodies. Ristocetin-induced aggregation was inhibited in 4 of these patients, and 2 with prominent inhibition had anti-GPIb antibodies. There was a significant relationship between platelet-associated IgG value and ATP secretion. These results suggest that some antiplatelet autoantibodies can affect platelet function and thus have an influence on the pathophysiology of ITP.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0902-4441
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
101-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1995321-Adenosine Diphosphate,
pubmed-meshheading:1995321-Adenosine Triphosphate,
pubmed-meshheading:1995321-Adolescent,
pubmed-meshheading:1995321-Adult,
pubmed-meshheading:1995321-Aged,
pubmed-meshheading:1995321-Aged, 80 and over,
pubmed-meshheading:1995321-Autoantibodies,
pubmed-meshheading:1995321-Blood Platelets,
pubmed-meshheading:1995321-Blotting, Western,
pubmed-meshheading:1995321-Child,
pubmed-meshheading:1995321-Collagen,
pubmed-meshheading:1995321-Female,
pubmed-meshheading:1995321-Flow Cytometry,
pubmed-meshheading:1995321-Humans,
pubmed-meshheading:1995321-Male,
pubmed-meshheading:1995321-Middle Aged,
pubmed-meshheading:1995321-Platelet Aggregation,
pubmed-meshheading:1995321-Platelet Membrane Glycoproteins,
pubmed-meshheading:1995321-Purpura, Thrombocytopenic,
pubmed-meshheading:1995321-Ristocetin
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pubmed:year |
1991
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pubmed:articleTitle |
Influences of antiplatelet autoantibodies on platelet function in immune thrombocytopenic purpura.
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pubmed:affiliation |
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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