|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2009-12-17
|
|
pubmed:abstractText |
The teratogenic effects of the anti-epileptic drug phenytoin have been linked to genetic differences in phenytoin disposition. The goal of this study was to assess the effect of maternal genotype of functional polymorphisms in two genes involved in phenytoin metabolism, CYP2C9 (R144C, I395L) and EPHX1 (Y113H, H139R), on the presence of major craniofacial abnormalities (CFAs) in the child.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
1744-6880
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
20
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
58-63
|
|
pubmed:dateRevised |
2010-5-21
|
|
pubmed:meshHeading |
pubmed-meshheading:19952982-Abnormalities, Drug-Induced,
pubmed-meshheading:19952982-Adolescent,
pubmed-meshheading:19952982-Adult,
pubmed-meshheading:19952982-Anticonvulsants,
pubmed-meshheading:19952982-Confidence Intervals,
pubmed-meshheading:19952982-Craniofacial Abnormalities,
pubmed-meshheading:19952982-Epoxide Hydrolases,
pubmed-meshheading:19952982-Female,
pubmed-meshheading:19952982-Genotype,
pubmed-meshheading:19952982-Haplotypes,
pubmed-meshheading:19952982-Humans,
pubmed-meshheading:19952982-Logistic Models,
pubmed-meshheading:19952982-Odds Ratio,
pubmed-meshheading:19952982-Phenytoin,
pubmed-meshheading:19952982-Polymorphism, Genetic,
pubmed-meshheading:19952982-Polymorphism, Single Nucleotide,
pubmed-meshheading:19952982-Pregnancy,
pubmed-meshheading:19952982-Risk Factors,
pubmed-meshheading:19952982-Young Adult
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Maternal EPHX1 polymorphisms and risk of phenytoin-induced congenital malformations.
|
|
pubmed:affiliation |
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, Maryland 20852, USA. azzatoe2@mail.nih.gov
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
|
