rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-12-22
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pubmed:abstractText |
Here we give context to new data on neonatal diabetes mellitus, a rare group of insulin-requiring monogenic forms of diabetes presenting at birth or shortly thereafter. Genetic studies are critical in the diagnosis and treatment of these patients. The most common causes of neonatal diabetes are activating mutations in the two protein subunits of the ATP-sensitive potassium channel. These are responsible for about half of all cases of permanent neonatal diabetes and some cases of transient neonatal diabetes. Identification of these mutations allows patients treated with insulin to be transferred to sulfonylureas, but associated conditions and other causes must be considered.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/EIF2AK3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/FOXP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Glucokinase,
http://linkedlifedata.com/resource/pubmed/chemical/Hypoglycemic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/KATP Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonylurea Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/eIF-2 Kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1752-2978
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
13-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19952737-Chromosomes, Human, Pair 6,
pubmed-meshheading:19952737-Developmental Disabilities,
pubmed-meshheading:19952737-Diabetes Mellitus, Type 1,
pubmed-meshheading:19952737-Epilepsy,
pubmed-meshheading:19952737-Forkhead Transcription Factors,
pubmed-meshheading:19952737-Glucokinase,
pubmed-meshheading:19952737-Humans,
pubmed-meshheading:19952737-Hypoglycemic Agents,
pubmed-meshheading:19952737-Infant, Newborn,
pubmed-meshheading:19952737-Insulin,
pubmed-meshheading:19952737-Insulin-Secreting Cells,
pubmed-meshheading:19952737-KATP Channels,
pubmed-meshheading:19952737-Mutation,
pubmed-meshheading:19952737-Sulfonylurea Compounds,
pubmed-meshheading:19952737-Syndrome,
pubmed-meshheading:19952737-eIF-2 Kinase
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pubmed:year |
2010
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pubmed:articleTitle |
Update in neonatal diabetes.
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pubmed:affiliation |
Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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