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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-12-2
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pubmed:abstractText |
Skeletal muscle structure and function are dependent on intact innervation. Prolonged muscle denervation results in irreversible muscle fiber atrophy, connective tissue hyperplasia, and deterioration of muscle spindles, specialized sensory receptors necessary for proper skeletal muscle function. The protective effect of temporary sensory innervation on denervated muscle, before motor nerve repair, has been shown in the rat. Sensory-protected muscles exhibit less fiber atrophy and connective tissue hyperplasia and maintain greater functional capacity than denervated muscles. The purpose of this study was to determine whether temporary sensory innervation also protects muscle spindles from degeneration.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1529-4242
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1860-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19952642-Analysis of Variance,
pubmed-meshheading:19952642-Animals,
pubmed-meshheading:19952642-Disease Models, Animal,
pubmed-meshheading:19952642-Electromyography,
pubmed-meshheading:19952642-Immunohistochemistry,
pubmed-meshheading:19952642-Muscle, Skeletal,
pubmed-meshheading:19952642-Muscle Denervation,
pubmed-meshheading:19952642-Muscle Spindles,
pubmed-meshheading:19952642-Nerve Regeneration,
pubmed-meshheading:19952642-Neural Conduction,
pubmed-meshheading:19952642-Peripheral Nerve Injuries,
pubmed-meshheading:19952642-Peripheral Nerves,
pubmed-meshheading:19952642-Probability,
pubmed-meshheading:19952642-Random Allocation,
pubmed-meshheading:19952642-Rats,
pubmed-meshheading:19952642-Rats, Inbred Lew,
pubmed-meshheading:19952642-Recovery of Function,
pubmed-meshheading:19952642-Sensory Thresholds,
pubmed-meshheading:19952642-Tibial Nerve
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pubmed:year |
2009
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pubmed:articleTitle |
Sensory protection of rat muscle spindles following peripheral nerve injury and reinnervation.
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pubmed:affiliation |
Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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