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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-2-22
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pubmed:abstractText |
IL-23 is a key cytokine in promotion of chronic inflammation. Here, we address if its pro-inflammatory potential can be harnessed to protect against chronic cryptococcosis. Mice were infected with Cryptococcus neoformans and treated with recombinant IL-23. Administration of IL-23 led to prolonged survival and reduced fungal burden but was inferior to IL-12 treatment. Independent of endogenous IL-23/IL-12, IL-23 treatment induced an altered cytokine profile accompanied by marked changes in composition of the inflammatory infiltrate characterized by T cell and dendritic cell recruitment. Although IL-23 induced hallmarks of the T(h)17 pathway, also non-T cells produced IL-17A and IL-22. IL-23 treatment of T-cell-deficient mice resulted in increased IL-17A and IL-22 production and modulation of the cellular response at the site of infection with elevated expression of CD86 on macrophages. Our data show that IL-23 treatment induces innate and adaptive tissue inflammation with limited impact on resistance to chronic cryptococcosis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antifungal Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Inflammation Mediators,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12 Subunit p40,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-23,
http://linkedlifedata.com/resource/pubmed/chemical/RAG-1 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Rag2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1460-2377
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
81-90
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pubmed:meshHeading |
pubmed-meshheading:19951959-Adaptive Immunity,
pubmed-meshheading:19951959-Animals,
pubmed-meshheading:19951959-Antifungal Agents,
pubmed-meshheading:19951959-Cells, Cultured,
pubmed-meshheading:19951959-Cryptococcosis,
pubmed-meshheading:19951959-Cryptococcus neoformans,
pubmed-meshheading:19951959-Cytokines,
pubmed-meshheading:19951959-DNA-Binding Proteins,
pubmed-meshheading:19951959-Dendritic Cells,
pubmed-meshheading:19951959-Disease Models, Animal,
pubmed-meshheading:19951959-Homeodomain Proteins,
pubmed-meshheading:19951959-Immunity, Innate,
pubmed-meshheading:19951959-Inflammation Mediators,
pubmed-meshheading:19951959-Interleukin-12,
pubmed-meshheading:19951959-Interleukin-12 Subunit p40,
pubmed-meshheading:19951959-Interleukin-23,
pubmed-meshheading:19951959-Macrophages,
pubmed-meshheading:19951959-Mice,
pubmed-meshheading:19951959-Mice, Inbred C57BL,
pubmed-meshheading:19951959-Mice, Knockout,
pubmed-meshheading:19951959-Recombinant Proteins,
pubmed-meshheading:19951959-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:19951959-Time Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Administration of IL-23 engages innate and adaptive immune mechanisms during fungal infection.
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pubmed:affiliation |
Institute of Immunology, College of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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