Source:http://linkedlifedata.com/resource/pubmed/id/19951958
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2009-12-18
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| pubmed:abstractText |
Dalton's lymphoma (DL) is a transplantable T-cell lymphoma of spontaneous origin, characterized by highly invasive and immunosuppressive property. Progression of DL cells results into an imbalance of T helper type 1 (T(h)1)/T helper type 2 (T(h)2)-type cytokine in the host, which is partly responsible for DL-induced severe immunosuppression and DL cell progression. In this study, we have shown the role of IL-13 in the regulation of T(h)1 immunity in both normal healthy and DL-bearing host. IL-13 pre-treatment inhibits the induction of 2,4-dinitro-1-fluorobenzene-induced contact hypersensitivity and delayed-type hypersensitivity (DTH) in antigen-challenged mice, which have been confirmed by neutralizing IL-13 by systemic delivery of non-signaling decoy receptor IL-13Ralpha2. Furthermore, IL-13 neutralization enhances the splenocyte proliferation, which has been inhibited by IL-13 administration. Adoptive transfer of splenocyte from IL-13-pre-treated mice and macrophages incubated with IL-13 and pulsed with antigens suppresses the DTH as well in antigen-challenged recipient mice. In addition, it also suppresses the production of pro-inflammatory cytokine and C-C chemokine in DTH footpad. Furthermore, IL-13 neutralization not only enhances the DTH reaction but also increases longevity and survival of DL-bearing host, which suggests that blocking/inactivating systemic IL-13 enhances T(h)1 immunity, and therefore, effects to diminish IL-13 production may have therapeutic value in a host bearing T-cell lymphoma.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,5-difluoro-2,4-dinitrobenzene,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL3,
http://linkedlifedata.com/resource/pubmed/chemical/Dinitrofluorobenzene,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-13,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-13 Receptor alpha2...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
1460-2377
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
53-63
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| pubmed:meshHeading |
pubmed-meshheading:19951958-Adoptive Transfer,
pubmed-meshheading:19951958-Animals,
pubmed-meshheading:19951958-Antigens, Neoplasm,
pubmed-meshheading:19951958-Cell Proliferation,
pubmed-meshheading:19951958-Cells, Cultured,
pubmed-meshheading:19951958-Chemokine CCL3,
pubmed-meshheading:19951958-Dermatitis, Contact,
pubmed-meshheading:19951958-Dinitrofluorobenzene,
pubmed-meshheading:19951958-Hypersensitivity, Delayed,
pubmed-meshheading:19951958-Interferon-gamma,
pubmed-meshheading:19951958-Interleukin-13,
pubmed-meshheading:19951958-Interleukin-13 Receptor alpha2 Subunit,
pubmed-meshheading:19951958-Lymphocyte Activation,
pubmed-meshheading:19951958-Lymphoma, T-Cell,
pubmed-meshheading:19951958-Mice,
pubmed-meshheading:19951958-Mice, Inbred BALB C,
pubmed-meshheading:19951958-Neoplasm Transplantation,
pubmed-meshheading:19951958-Th1 Cells,
pubmed-meshheading:19951958-Th2 Cells
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| pubmed:year |
2010
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| pubmed:articleTitle |
IL-13 from Th2-type cells suppresses induction of antigen-specific Th1 immunity in a T-cell lymphoma.
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| pubmed:affiliation |
Centre of Advanced Study in Zoology, Department of Zoology, Faculty of Science, Banaras Hindu University, Varanasi 221 005, Uttar Pradesh, India.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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