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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-3-24
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pubmed:abstractText |
Tumour necrosis factor alpha (TNFalpha) is a focal point of the inflammatory cascade in Crohn's disease (CD). As an emerging approach to block cytokines, antisense oligonucleotide (ASO) has developed quickly, but is thwarted by a key obstacle-safe and effective delivery to specified cells. Here a novel nano-complex, based on galactosylated low molecular weight chitosan (gal-LMWC) and an ASO against TNFalpha, is presented which may be effective for CD treatment. The aim of this study was to investigate the targeting delivery ability of the gal-LMWC/ASO complex into activated macrophages and its potential therapeutic action in experimental colitis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1468-3288
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
470-9
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pubmed:meshHeading |
pubmed-meshheading:19951904-Animals,
pubmed-meshheading:19951904-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19951904-Chronic Disease,
pubmed-meshheading:19951904-Colitis,
pubmed-meshheading:19951904-Colon,
pubmed-meshheading:19951904-Cytokines,
pubmed-meshheading:19951904-Disease Models, Animal,
pubmed-meshheading:19951904-Female,
pubmed-meshheading:19951904-Gene Targeting,
pubmed-meshheading:19951904-Gene Therapy,
pubmed-meshheading:19951904-Genetic Vectors,
pubmed-meshheading:19951904-Inflammation Mediators,
pubmed-meshheading:19951904-Intestinal Mucosa,
pubmed-meshheading:19951904-Macrophages, Peritoneal,
pubmed-meshheading:19951904-Mice,
pubmed-meshheading:19951904-Mice, Inbred BALB C,
pubmed-meshheading:19951904-Mice, SCID,
pubmed-meshheading:19951904-Oligonucleotides, Antisense,
pubmed-meshheading:19951904-Transfection,
pubmed-meshheading:19951904-Trinitrobenzenesulfonic Acid,
pubmed-meshheading:19951904-Tumor Necrosis Factor-alpha
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pubmed:year |
2010
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pubmed:articleTitle |
Targeting delivery of anti-TNFalpha oligonucleotide into activated colonic macrophages protects against experimental colitis.
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pubmed:affiliation |
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, China. jfzhang@nju.edu.cn
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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