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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-12-16
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pubmed:abstractText |
Fibroblast-like synoviocytes (FLS) are a major component of the hyperplastic synovial pannus that aggressively invades cartilage and bone during the course of rheumatoid arthritis (RA). Cyr61 (CCN1) is a product of a growth factor-inducible immediate early gene and is involved in cell adhesion, proliferation, and differentiation. However, the role that Cyr61 plays in FLS proliferation has remained undetermined. The aim of this study was to identify the role of Cyr61 in regulating the proliferation of FLS derived from patients with RA.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0004-3591
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pubmed:author |
pubmed-author:DulRR,
pubmed-author:HeDongyiD,
pubmed-author:LiDangshengD,
pubmed-author:LiNingliN,
pubmed-author:LinJinpiaoJ,
pubmed-author:OuyangGuilinG,
pubmed-author:ShenBaihuaB,
pubmed-author:ShiYuanY,
pubmed-author:WangLiL,
pubmed-author:WuJuanjuanJ,
pubmed-author:XiaoLianboL,
pubmed-author:ZhangQiuyuQ,
pubmed-author:ZhangYanY
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3602-12
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pubmed:meshHeading |
pubmed-meshheading:19950293-Adult,
pubmed-meshheading:19950293-Aged,
pubmed-meshheading:19950293-Antibodies, Neutralizing,
pubmed-meshheading:19950293-Arthritis, Rheumatoid,
pubmed-meshheading:19950293-Cell Proliferation,
pubmed-meshheading:19950293-Cells, Cultured,
pubmed-meshheading:19950293-Cysteine-Rich Protein 61,
pubmed-meshheading:19950293-Female,
pubmed-meshheading:19950293-Gene Expression Regulation,
pubmed-meshheading:19950293-Gene Silencing,
pubmed-meshheading:19950293-Humans,
pubmed-meshheading:19950293-Interleukin-17,
pubmed-meshheading:19950293-Male,
pubmed-meshheading:19950293-Middle Aged,
pubmed-meshheading:19950293-Osteoarthritis,
pubmed-meshheading:19950293-RNA Interference,
pubmed-meshheading:19950293-Synovial Fluid,
pubmed-meshheading:19950293-Synovial Membrane
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pubmed:year |
2009
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pubmed:articleTitle |
A critical role of Cyr61 in interleukin-17-dependent proliferation of fibroblast-like synoviocytes in rheumatoid arthritis.
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pubmed:affiliation |
Shanghai Jiao Tong University School of Medicine, and Guanghua Rheumatology Hospital, Shanghai, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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