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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0030705,
umls-concept:C0185117,
umls-concept:C0302592,
umls-concept:C0332293,
umls-concept:C0387583,
umls-concept:C0475276,
umls-concept:C0871261,
umls-concept:C1280500,
umls-concept:C1522449,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:issue |
6
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pubmed:dateCreated |
2009-12-1
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pubmed:abstractText |
We investigated the correlation between Cyclooxygenase-2 (COX-2) expression and the tumor response in patients with cervical cancer that were treated with curative radiotherapy (RT). Fifty-seven patients with squamous cell carcinoma were treated with concurrent radiochemotherapy (CRCT, n=29) or RT alone (n=28). The response of each patient was evaluated by three serial Magnetic Resonance Imaging examinations: before the start of RT, at four weeks after the start of RT (mid-RT) and at four weeks after the completion of RT (post-RT). Forty-three patients had positive COX-2 expression. The COX-2 negative patients achieved a higher rate of complete response (CR) at mid-RT than did the COX-2 positive patients (28.6% vs. 7.0%, P=0.054), but not at post-RT (64.3% vs. 69.8%). The initial tumor volume was a significant predictor of CR at mid-RT (P=0.003) and post-RT (P=0.004). The multivariate analysis showed that the initial tumor volume (at mid-RT and post-RT) and CRCT (at post-RT) were significant predictors of CR; however, the COX-2 expression was not. In conclusion, the COX-2 expression status has no significant correlation with the tumor response. Further studies on the changes in COX-2 expression levels during RT may be helpful for determination of its role in the tumor response to treatment and patient prognosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-10022645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-10202164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-10202165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-10202166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-10341691,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-10517428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-10684704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-10974444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-11586093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-12209745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-14519750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-14528092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-15111350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-15173710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-15465199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-15786748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-16099602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-16213106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-16317264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-16905208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-16979845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-17207548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-17249380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-17308999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-17511025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-17881290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-18353631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-18392637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19949677-9809985
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1598-6357
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pubmed:author |
pubmed-author:AhnGeunghwanG,
pubmed-author:AhnYong ChanYC,
pubmed-author:BaeDuk SooDS,
pubmed-author:ChoEun YoonEY,
pubmed-author:ChoiYoon-LaYL,
pubmed-author:HuhSeung JaeSJ,
pubmed-author:KangMin KyuMK,
pubmed-author:KimByoung GieBG,
pubmed-author:LimDo Hoondo H,
pubmed-author:NamHeerimH,
pubmed-author:OhDong RyulDR,
pubmed-author:ParkWonW
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1170-6
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
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pubmed:year |
2009
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pubmed:articleTitle |
The effect of cyclooxygenase-2 expression on tumor volume response in patients treated with radiotherapy for uterine cervical cancer.
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pubmed:affiliation |
Department of Radiation and Oncology, Yeungnam University College of Medicine, Daegu, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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