| pubmed-article:19949374 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19949374 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:19949374 | lifeskim:mentions | umls-concept:C0664336 | lld:lifeskim |
| pubmed-article:19949374 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:19949374 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19949374 | lifeskim:mentions | umls-concept:C1419771 | lld:lifeskim |
| pubmed-article:19949374 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19949374 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19949374 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19949374 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19949374 | pubmed:dateCreated | 2010-2-1 | lld:pubmed |
| pubmed-article:19949374 | pubmed:abstractText | Previously we described that bone morphogenetic protein-7 (BMP7) could protect prostate cancer C4-2B cells from serum starvation-induced apoptosis via survivin induction. Here, for the first time, we identify Runx2 as a key regulator of survivin transcription. In C4-2B cells grown normally, suppression of Runx2 reduced survivin expression. Using ChIP assays, two regions of the survivin promoter, -1953 to -1812 (I) and -1485 to -1119 (II) encompassing consensus Runx-binding sites were examined. Runx2 was found to be associated with both regions, with a stronger affinity to region-I. In serum-starved cells neither region was occupied, but BMP7 restored association to region-II and not region-I. In reporter assays, transcription activity by BMP7 was significantly reduced when sequences including binding sites of region-II were deleted. Additionally, Runx2 expression was enhanced by BMP7 in these cells. Along with a strong survivin expression, a trend in increased Runx2 expression in human prostate cancer cells and tissues was noted. In the conditional Pten-knockout mouse, Runx2 level increased with growth of prostate tumor. The data define a novel role of Runx2 in regulating survivin expression in malignant epithelial cells and identify it as a critical factor in BMP signaling that protects cancer cells against apoptosis. | lld:pubmed |
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| pubmed-article:19949374 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19949374 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19949374 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19949374 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19949374 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:19949374 | pubmed:issn | 1530-0307 | lld:pubmed |
| pubmed-article:19949374 | pubmed:author | pubmed-author:CohenMichael... | lld:pubmed |
| pubmed-article:19949374 | pubmed:author | pubmed-author:ChenZhongZ | lld:pubmed |
| pubmed-article:19949374 | pubmed:author | pubmed-author:Roy-BurmanPra... | lld:pubmed |
| pubmed-article:19949374 | pubmed:author | pubmed-author:YangShangxinS | lld:pubmed |
| pubmed-article:19949374 | pubmed:author | pubmed-author:LimMinyoungM | lld:pubmed |
| pubmed-article:19949374 | pubmed:author | pubmed-author:BellAdam MAM | lld:pubmed |
| pubmed-article:19949374 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19949374 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:19949374 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19949374 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19949374 | pubmed:pagination | 222-33 | lld:pubmed |
| pubmed-article:19949374 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:19949374 | pubmed:meshHeading | pubmed-meshheading:19949374... | lld:pubmed |
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| pubmed-article:19949374 | pubmed:meshHeading | pubmed-meshheading:19949374... | lld:pubmed |
| pubmed-article:19949374 | pubmed:meshHeading | pubmed-meshheading:19949374... | lld:pubmed |
| pubmed-article:19949374 | pubmed:meshHeading | pubmed-meshheading:19949374... | lld:pubmed |
| pubmed-article:19949374 | pubmed:meshHeading | pubmed-meshheading:19949374... | lld:pubmed |
| pubmed-article:19949374 | pubmed:meshHeading | pubmed-meshheading:19949374... | lld:pubmed |
| pubmed-article:19949374 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:19949374 | pubmed:articleTitle | Runx2 regulates survivin expression in prostate cancer cells. | lld:pubmed |
