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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1991-3-19
|
| pubmed:abstractText |
We performed a 10-year retrospective analysis of the frequency of local postoperative infectious complications in methotrexate (MTX)-treated rheumatoid arthritis patients who underwent total joint arthroplasty. Sixty patients, who had a total of 92 joint arthroplasties, were receiving MTX. A comparison group of 61 patients with a combined total of 110 total joint arthroplasties were not receiving MTX. The 2 groups were compared for the occurrence of local postoperative infectious complications and poor wound healing. Eight patients in the MTX group experienced a total of 8 complications (8.7% of procedures). In comparison, 5 patients in the non-MTX group experienced a total of 6 complications (5.5% of procedures), a difference that was not statistically significant (chi 2 = 0.816, P = 0.366). Statistical analysis of many other variables revealed none that could be identified as risk factors for postoperative complications. These results suggest that treatment in the perioperative period with weekly low-dose pulse MTX does not increase the risk of local postoperative infectious complications or poor wound healing in rheumatoid arthritis patients who undergo total joint arthroplasty.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0004-3591
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
146-52
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1994911-Adrenal Cortex Hormones,
pubmed-meshheading:1994911-Adult,
pubmed-meshheading:1994911-Aged,
pubmed-meshheading:1994911-Aged, 80 and over,
pubmed-meshheading:1994911-Arthritis, Rheumatoid,
pubmed-meshheading:1994911-Drug Therapy, Combination,
pubmed-meshheading:1994911-Female,
pubmed-meshheading:1994911-Folic Acid,
pubmed-meshheading:1994911-Humans,
pubmed-meshheading:1994911-Incidence,
pubmed-meshheading:1994911-Knee Prosthesis,
pubmed-meshheading:1994911-Male,
pubmed-meshheading:1994911-Methotrexate,
pubmed-meshheading:1994911-Middle Aged,
pubmed-meshheading:1994911-Prednisone,
pubmed-meshheading:1994911-Reoperation,
pubmed-meshheading:1994911-Retrospective Studies,
pubmed-meshheading:1994911-Surgical Wound Dehiscence,
pubmed-meshheading:1994911-Surgical Wound Infection
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Local infectious complications following large joint replacement in rheumatoid arthritis patients treated with methotrexate versus those not treated with methotrexate.
|
| pubmed:affiliation |
Department of Rheumatic and Immunologic Disease, Cleveland Clinic Foundation, Ohio 44195-5028.
|
| pubmed:publicationType |
Journal Article
|