| pubmed-article:19948478 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19948478 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:19948478 | lifeskim:mentions | umls-concept:C0083792 | lld:lifeskim |
| pubmed-article:19948478 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:19948478 | lifeskim:mentions | umls-concept:C1420667 | lld:lifeskim |
| pubmed-article:19948478 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19948478 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:19948478 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:19948478 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:19948478 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:19948478 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19948478 | pubmed:dateCreated | 2009-12-1 | lld:pubmed |
| pubmed-article:19948478 | pubmed:abstractText | Nodal and Notch signaling pathways play essential roles in vertebrate development. Through a yeast two-hybrid screening, we identified Notch3 as a candidate binding partner of the Nodal coreceptor Cripto-1. Coimmunoprecipitation analysis confirmed the binding of Cripto-1 with all four mammalian Notch receptors. Deletion analyses revealed that the binding of Cripto-1 and Notch1 is mediated by the Cripto-1/FRL-1/Cryptic domain of Cripto-1 and the C-terminal region of epidermal growth factor-like repeats of Notch1. Binding of Cripto-1 to Notch1 occurred mainly in the endoplasmic reticulum-Golgi network. Cripto-1 expression resulted in the recruitment of Notch1 protein into lipid raft microdomains and enhancement of the furin-like protein convertase-mediated proteolytic maturation of Notch1 (S1 cleavage). Enhanced S1 cleavage resulted in the sensitization to ligand-induced activation of Notch signaling. In addition, knockdown of Cripto-1 expression in human and mouse embryonal carcinoma cells desensitized the ligand-induced Notch signaling activation. These results suggest a novel role of Cripto-1 in facilitating the posttranslational maturation of Notch receptors. | lld:pubmed |
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| pubmed-article:19948478 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19948478 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19948478 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19948478 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19948478 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19948478 | pubmed:issn | 1540-8140 | lld:pubmed |
| pubmed-article:19948478 | pubmed:author | pubmed-author:SakamotoKeiK | lld:pubmed |
| pubmed-article:19948478 | pubmed:author | pubmed-author:SalomonDavid... | lld:pubmed |
| pubmed-article:19948478 | pubmed:author | pubmed-author:LeeJoseph MJM | lld:pubmed |
| pubmed-article:19948478 | pubmed:author | pubmed-author:BiancoCaterin... | lld:pubmed |
| pubmed-article:19948478 | pubmed:author | pubmed-author:SunYoupingY | lld:pubmed |
| pubmed-article:19948478 | pubmed:author | pubmed-author:WatanabeKazuh... | lld:pubmed |
| pubmed-article:19948478 | pubmed:author | pubmed-author:CallahanRober... | lld:pubmed |
| pubmed-article:19948478 | pubmed:author | pubmed-author:NagaokaTadahi... | lld:pubmed |
| pubmed-article:19948478 | pubmed:author | pubmed-author:GonzalesMonic... | lld:pubmed |
| pubmed-article:19948478 | pubmed:author | pubmed-author:CastroNadia... | lld:pubmed |
| pubmed-article:19948478 | pubmed:author | pubmed-author:RangelMaria... | lld:pubmed |
| pubmed-article:19948478 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19948478 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:19948478 | pubmed:volume | 187 | lld:pubmed |
| pubmed-article:19948478 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19948478 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19948478 | pubmed:pagination | 343-53 | lld:pubmed |
| pubmed-article:19948478 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:19948478 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19948478 | pubmed:articleTitle | Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1. | lld:pubmed |
| pubmed-article:19948478 | pubmed:affiliation | Mammary Biology and Tumorigenesis Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:19948478 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19948478 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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