Linked Life Data

199473

Source:http://linkedlifedata.com/resource/pubmed/id/199473

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1977-12-29
pubmed:abstractText
In a stress due to 30-min immobilization, the initial stages of the thrombin clearance in the blood flow of rats are considerably accelerated. Thus, in 5 min after i.v. administration of thrombin I131, The blood relative radioactivity in experimental rats decreases by about 40% while in the control animals--by 20%. The same stress against the background of exogenous ACTH leads to a still greater acceleration of the thrombin clearance and the blood relative radioactivity within the 5 min decreases by 55%. The accelerated clearance of the thrombin I131 from the blood during immobilization and combination of the latter with ACTH administration is followed by its accumulation in the liver and its reduction in the lungs. The activating effect of ACTH on the thrombin I131 clearance is not, apparently, mediated through activation of the adrenal glucocorticoid function as the clearance initial stages are not accelerated after hydrocortisone administration. The clearance depends on the heparin contents in the blood: binding of endogenous heparin with protamine--sulphate leads to abolishing of the stress activating effect, and the speed of clearance in immobilized animals decreases to basal level of control animals.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0015-329X
pubmed:author
pubmed:issnType
Print
pubmed:volume
63
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1295-1301
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
[Acceleration of the initial stages of thrombin clearance in the bloodstream of rats during stress].
pubmed:publicationType
Journal Article, English Abstract