Linked Life Data

19947162

Source:http://linkedlifedata.com/resource/pubmed/id/19947162

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-12-1
pubmed:abstractText
Recently, the worldwide spread of A/H5N1 avian influenza with high virulence has highlighted the potential threat of a human influenza pandemic. The viral surface glycoprotein, neuraminidase (NA), has been found to be a potential target to control influenza virus. With an understanding of the enzyme mechanism, the X-ray crystallographic structures of NA and its substrate or inhibitors, and progress in computational chemistry, the information about NA binding sites and pharmacophore models is derived from existing inhibitors and will serve as design guidelines of more potent agents against NA. This article gives a systematic review of the recent advances in this area.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0031-7144
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
627-32
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Pharmacophore model of influenza neuraminidase inhibitors--a systematic review.
pubmed:affiliation
Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji'nan, Shandong, PR China. drgongjianzhi@yahoo.com.cn
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't