Linked Life Data

19946892

Source:http://linkedlifedata.com/resource/pubmed/id/19946892

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2009-12-3
pubmed:abstractText
Uncoupling proteins (UCPs) belong to a family of mitochondrial carrier proteins that are present in the mitochondrial inner membrane. Genetic and experimental studies have shown that UCP dysfunction can be involved in metabolic disorders and in obesity. Uncoupling protein-1 (UCP1; also known as thermogenin) was identified in 1988 and found to be highly expressed in brown adipose tissue. UCP1 allows the leak of protons in respiring mitochondria, dissipating the energy as heat; the enzyme has an important role in nonshivering heat production induced by cold exposure or food intake. In 1997, two homologs of UCP1 were identified and named UCP2 and UCP3. These novel proteins also lower mitochondrial membrane potential, but whether they can dissipate metabolic energy as heat as efficiently as UCP1 is open to dispute. Even after a decade of study, the physiological roles of these novel proteins have still not been completely elucidated. This review aims to shed light on the nutritional and hormonal regulation of UCP2 and on its physiological roles.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1521-6551
pubmed:author
pubmed:copyrightInfo
(c) 2009 IUBMB
pubmed:issnType
Electronic
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1123-31
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Nutritional and hormonal regulation of uncoupling protein 2.
pubmed:affiliation
Division of Basic Molecular Science and Molecular Medicine, School of Medicine, Tokai University, Bohseidai, Ishehara, Kanagawa, Japan. yonet2301@yahoo.co.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't