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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2009-11-30
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pubmed:abstractText |
Vitamin D analogs may slow the progression of chronic kidney disease. Tan et al. report that paricalcitol has additive effects with an angiotensin-converting enzyme inhibitor (ACEI) in suppressing extracellular matrix expression, interstitial inflammation, and myofibroblast activation in obstructive nephropathy. Paricalcitol inhibited renin transcription, countering the compensatory ACEI-induced rise in renin, thus achieving a more complete blockade of the renin-angiotensin system (RAS). Vitamin D analogs may enhance the renoprotective effects of RAS inhibitors.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1523-1755
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1219-21
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pubmed:meshHeading |
pubmed-meshheading:19946310-Angiotensin II Type 1 Receptor Blockers,
pubmed-meshheading:19946310-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:19946310-Animals,
pubmed-meshheading:19946310-Drug Synergism,
pubmed-meshheading:19946310-Ergocalciferols,
pubmed-meshheading:19946310-Humans,
pubmed-meshheading:19946310-Models, Biological,
pubmed-meshheading:19946310-Renal Insufficiency, Chronic,
pubmed-meshheading:19946310-Renin-Angiotensin System,
pubmed-meshheading:19946310-Vitamin D
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pubmed:year |
2009
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pubmed:articleTitle |
Vitamin D: a new hope for chronic kidney disease?
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pubmed:affiliation |
Section of Nephrology and Hypertension, Department of Medicine, Tulane University School of Medicine, Section of Nephrology and Hypertension, New Orleans, Louisiana 70112, USA. minlee@tulane.edu
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pubmed:publicationType |
Journal Article,
Comment,
Review,
Research Support, Non-U.S. Gov't
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