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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2009-12-28
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pubmed:abstractText |
Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 x 10(-10); ancestry-adjusted OR=1.79, P=1.9 x 10(-5)).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1546-1718
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-3
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pubmed:dateRevised |
2010-4-7
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pubmed:meshHeading |
pubmed-meshheading:19946271-Adult,
pubmed-meshheading:19946271-Female,
pubmed-meshheading:19946271-Gene Frequency,
pubmed-meshheading:19946271-Genetic Predisposition to Disease,
pubmed-meshheading:19946271-Genetic Variation,
pubmed-meshheading:19946271-Genotype,
pubmed-meshheading:19946271-Humans,
pubmed-meshheading:19946271-Lipase,
pubmed-meshheading:19946271-Liver Cirrhosis, Alcoholic,
pubmed-meshheading:19946271-Liver Diseases, Alcoholic,
pubmed-meshheading:19946271-Logistic Models,
pubmed-meshheading:19946271-Male,
pubmed-meshheading:19946271-Membrane Proteins,
pubmed-meshheading:19946271-Middle Aged,
pubmed-meshheading:19946271-Polymorphism, Single Nucleotide
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pubmed:year |
2010
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pubmed:articleTitle |
Variant in PNPLA3 is associated with alcoholic liver disease.
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pubmed:affiliation |
Perlegen Sciences, Mountain View, California, USA.
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pubmed:publicationType |
Journal Article
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