Linked Life Data

19945459

Source:http://linkedlifedata.com/resource/pubmed/id/19945459

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
2010-4-5
pubmed:abstractText
Pheromones have been shown to induce sexually dimorphic responses in LH secretion. Here we asked whether the sexually dimorphic population of kisspeptin neurons in the rostral periventricular area of the third ventricle (RP3V) could relay sexually dimorphic information from the olfactory systems to the GnRH system. Furthermore, we analyzed the effects of aromatase mutation (ArKO) and thus the role of estradiol on RP3V kisspeptin neuronal numbers and on the response of these kisspeptin neurons to same- versus opposite-sex urinary pheromones. Exposure to male but not female urinary odors induced Fos protein in kisspeptin neurons in the RP3V of female wildtype (WT) mice, suggesting that these kisspeptin neurons may be part of the neural circuitry that relays information from the olfactory brain to the GnRH system in a sexually dimorphic manner. Male pheromones induced Fos in kisspeptin neurons in ArKO females, albeit significantly less compared to WT females. The sexual differentiation of kisspeptin neuronal number was lost in ArKO mice, i.e. the number of kisspeptin-immunoreactive neurons in the RP3V of ArKO females was as low as in male mice, whereas male ArKO mice had somewhat increased numbers of kisspeptin neurons. These results suggest that the sex difference in kisspeptin neuronal number in WT mice reflects an organizational action of estradiol in females. By contrast, the ability of male urinary pheromones to activate kisspeptin neurons in WT females may not depend on the organizational action of estradiol since ArKO females still showed some Fos/kisspeptin co-activation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1095-6867
pubmed:author
pubmed:copyrightInfo
Copyright 2009. Published by Elsevier Inc.
pubmed:issnType
Electronic
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
390-5
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:19945459-Animals, pubmed-meshheading:19945459-Aromatase, pubmed-meshheading:19945459-Cell Count, pubmed-meshheading:19945459-Data Interpretation, Statistical, pubmed-meshheading:19945459-Estradiol, pubmed-meshheading:19945459-Female, pubmed-meshheading:19945459-Immunohistochemistry, pubmed-meshheading:19945459-Kisspeptins, pubmed-meshheading:19945459-Male, pubmed-meshheading:19945459-Mice, pubmed-meshheading:19945459-Mice, Knockout, pubmed-meshheading:19945459-Mutation, pubmed-meshheading:19945459-Neurons, pubmed-meshheading:19945459-Odors, pubmed-meshheading:19945459-Olfactory Bulb, pubmed-meshheading:19945459-Proto-Oncogene Proteins c-fos, pubmed-meshheading:19945459-Sex Attractants, pubmed-meshheading:19945459-Sex Characteristics, pubmed-meshheading:19945459-Sex Differentiation, pubmed-meshheading:19945459-Smell, pubmed-meshheading:19945459-Tumor Suppressor Proteins
pubmed:year
2010
pubmed:articleTitle
Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones.
pubmed:affiliation
GIGA Neurosciences, University of Liège, B36 (1st floor). Avenue de l'Hopital, 1 4000, Liège, Belgium. j.bakker@ulg.ac.be
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural