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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1991-3-20
|
| pubmed:abstractText |
We studied the impairment of autoregulation of cerebral blood flow (CBF) and its effect on the electrical activity of the brain during the development of chronic cerebral vasospasm after subarachnoid hemorrhage, using a vasospasm model in primates. Fourteen animals were divided into two groups: a clot group (8) and a sham-operated group (6). To induce subarachnoid hemorrhage, all the animals underwent craniectomy, and in the clot group, the autologous blood clot was located around the arteries dissected free from the arachnoid membrane. Cerebral angiography was performed before subarachnoid hemorrhage and 7 days after (Day 7). On Day 7, regional CBF in the parietal lobe--measured by the hydrogen clearance method--and central conduction time were studied during either graded hypertension or hypotension. In the clot group, the mean vessel caliber of the cerebral arteries on the right side (clot side) of the circle of Willis showed significant (P less than 0.01) reduction (more than 40%) as compared with the values on the contralateral, non-clot side. The values for the bilateral parietal CBF in the sham-operated group and the left parietal CBF in the clot group were fairly constant when the mean arterial blood pressure (MABP) was in the range of 60 to 160 mm Hg. In the clot group, right parietal CBF was significantly (P less than 0.05) smaller than that on the left side at an MABP level of 40 to 100 mm Hg, and increased at an MABP level of 180 mm Hg. The right parietal CBF increased as the arterial blood pressure increased, showing impairment of autoregulation.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0148-396X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
41-8
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| pubmed:dateRevised |
2003-11-14
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| pubmed:meshHeading |
pubmed-meshheading:1994280-Animals,
pubmed-meshheading:1994280-Blood Pressure,
pubmed-meshheading:1994280-Cerebral Angiography,
pubmed-meshheading:1994280-Cerebral Arteries,
pubmed-meshheading:1994280-Cerebrovascular Circulation,
pubmed-meshheading:1994280-Electroencephalography,
pubmed-meshheading:1994280-Evoked Potentials, Somatosensory,
pubmed-meshheading:1994280-Homeostasis,
pubmed-meshheading:1994280-Ischemic Attack, Transient,
pubmed-meshheading:1994280-Macaca fascicularis,
pubmed-meshheading:1994280-Reaction Time,
pubmed-meshheading:1994280-Subarachnoid Hemorrhage
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Impairment of cerebral autoregulation during the development of chronic cerebral vasospasm after subarachnoid hemorrhage in primates.
|
| pubmed:affiliation |
Department of Neurosurgery, Fukui Medical School, Japan.
|
| pubmed:publicationType |
Journal Article
|