| pubmed-article:19940161 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19940161 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:19940161 | lifeskim:mentions | umls-concept:C0003009 | lld:lifeskim |
| pubmed-article:19940161 | lifeskim:mentions | umls-concept:C0031715 | lld:lifeskim |
| pubmed-article:19940161 | lifeskim:mentions | umls-concept:C0007367 | lld:lifeskim |
| pubmed-article:19940161 | lifeskim:mentions | umls-concept:C0020564 | lld:lifeskim |
| pubmed-article:19940161 | lifeskim:mentions | umls-concept:C0036720 | lld:lifeskim |
| pubmed-article:19940161 | lifeskim:mentions | umls-concept:C0013126 | lld:lifeskim |
| pubmed-article:19940161 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:19940161 | lifeskim:mentions | umls-concept:C0001038 | lld:lifeskim |
| pubmed-article:19940161 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:19940161 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19940161 | pubmed:dateCreated | 2010-1-18 | lld:pubmed |
| pubmed-article:19940161 | pubmed:abstractText | Angiotensin II (Ang II) is a pleuripotential hormone that is important in the pathophysiology of multiple conditions including aging, cardiovascular and renal diseases, and insulin resistance. Reactive oxygen species (ROS) are important mediators of Ang II-induced signaling generally and have a well defined role in vascular hypertrophy, which is inhibited by overexpression of catalase, inferring a specific role of H(2)O(2). The molecular mechanisms are understood incompletely. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) is a key regulator of energy metabolism and ROS-scavenging enzymes including catalase. We show that Ang II stimulates Akt-dependent PGC-1 alpha serine 570 phosphorylation, which is required for the binding of the histone acetyltransferase GCN5 (general control nonderepressible 5) to PGC-1 alpha and for its lysine acetylation. These sequential post-translational modifications suppress PGC-1 alpha activity and prevent its binding to the catalase promoter through the forkhead box O1 transcription factor, thus decreasing catalase expression. We demonstrate that overexpression of the phosphorylation-defective mutant PGC-1 alpha (S570A) prevents Ang II-induced increases in H(2)O(2) levels and hypertrophy ([(3)H]leucine incorporation). Knockdown of PGC-1 alpha by small interfering RNA promotes basal and Ang II-stimulated ROS and hypertrophy, which is reversed by polyethylene glycol-conjugated catalase. Thus, endogenous PGC-1 alpha is a negative regulator of vascular hypertrophy by up-regulating catalase expression and thus reducing ROS levels. We provide novel mechanistic insights by which Ang II may mediate its ROS-dependent pathophysiologic effects on multiple cardiometabolic diseases. | lld:pubmed |
| pubmed-article:19940161 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19940161 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19940161 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19940161 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19940161 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:19940161 | pubmed:author | pubmed-author:MaMinhuiM | lld:pubmed |
| pubmed-article:19940161 | pubmed:author | pubmed-author:AhmadMushtaqM | lld:pubmed |
| pubmed-article:19940161 | pubmed:author | pubmed-author:AlexanderR... | lld:pubmed |
| pubmed-article:19940161 | pubmed:author | pubmed-author:SalazarGloria... | lld:pubmed |
| pubmed-article:19940161 | pubmed:author | pubmed-author:Ushio-FukaiMa... | lld:pubmed |
| pubmed-article:19940161 | pubmed:author | pubmed-author:XiongShiqinS | lld:pubmed |
| pubmed-article:19940161 | pubmed:author | pubmed-author:HilenskiLulaL | lld:pubmed |
| pubmed-article:19940161 | pubmed:author | pubmed-author:PatrushevNiko... | lld:pubmed |
| pubmed-article:19940161 | pubmed:author | pubmed-author:San... | lld:pubmed |
| pubmed-article:19940161 | pubmed:author | pubmed-author:NazarewiczRaf... | lld:pubmed |
| pubmed-article:19940161 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19940161 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:19940161 | pubmed:volume | 285 | lld:pubmed |
