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pubmed-article:19935404pubmed:abstractTextEstimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain.lld:pubmed
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pubmed-article:19935404pubmed:articleTitleEstimation of plasma IC50 of donepezil for cerebral acetylcholinesterase inhibition in patients with Alzheimer disease using positron emission tomography.lld:pubmed
pubmed-article:19935404pubmed:affiliationDepartment of Molecular Probe, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan. ota@juntendo.ac.jplld:pubmed
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