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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0001044,
umls-concept:C0002395,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0030705,
umls-concept:C0032105,
umls-concept:C0032743,
umls-concept:C0228174,
umls-concept:C0527316,
umls-concept:C0600495,
umls-concept:C0680844,
umls-concept:C0681916,
umls-concept:C0750572
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|
pubmed:issue |
2
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pubmed:dateCreated |
2010-4-8
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pubmed:abstractText |
Estimate the value of in vivo plasma IC50 of donepezil, the concentration of donepezil in plasma that inhibits brain acetylcholinesterase (AChE) activity by 50% at the steady-state conditions of donepezil between the plasma and the brain.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:issn |
1537-162X
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pubmed:author |
pubmed-author:AraiHeiiH,
pubmed-author:FukushiKiyoshiK,
pubmed-author:HiranoShigekiS,
pubmed-author:IrieToshiakiT,
pubmed-author:KikuchiTatsuyaT,
pubmed-author:MiyoshiMichieM,
pubmed-author:OtaTsuneyoshiT,
pubmed-author:SatoKoichiK,
pubmed-author:ShimadaHitoshiH,
pubmed-author:ShinotohHitoshiH,
pubmed-author:SuharaTetsuyaT,
pubmed-author:TanakaNorikoN
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pubmed:issnType |
Electronic
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pubmed:volume |
33
|
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
74-8
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pubmed:meshHeading |
pubmed-meshheading:19935404-Acetylcholinesterase,
pubmed-meshheading:19935404-Aged,
pubmed-meshheading:19935404-Aged, 80 and over,
pubmed-meshheading:19935404-Alzheimer Disease,
pubmed-meshheading:19935404-Cerebral Cortex,
pubmed-meshheading:19935404-Cholinesterase Inhibitors,
pubmed-meshheading:19935404-Female,
pubmed-meshheading:19935404-Humans,
pubmed-meshheading:19935404-Indans,
pubmed-meshheading:19935404-Inhibitory Concentration 50,
pubmed-meshheading:19935404-Male,
pubmed-meshheading:19935404-Middle Aged,
pubmed-meshheading:19935404-Piperidines,
pubmed-meshheading:19935404-Positron-Emission Tomography
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pubmed:articleTitle |
Estimation of plasma IC50 of donepezil for cerebral acetylcholinesterase inhibition in patients with Alzheimer disease using positron emission tomography.
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pubmed:affiliation |
Department of Molecular Probe, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan. ota@juntendo.ac.jp
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pubmed:publicationType |
Journal Article,
Clinical Trial
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