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rdf:type |
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lifeskim:mentions |
umls-concept:C0005938,
umls-concept:C0017262,
umls-concept:C0037083,
umls-concept:C0205419,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1336645,
umls-concept:C1367028,
umls-concept:C1412836,
umls-concept:C1515655,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1710082,
umls-concept:C1710303
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pubmed:issue |
2
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pubmed:dateCreated |
2010-1-25
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pubmed:abstractText |
Receptor activator of nuclear factor-kappaB ligand/osteoprotegerin (RANKL/OPG) signaling system plays a crucial role in the regulation of bone resorption. Polymorphic variations in the genes may have an influence on gene expression and bone metabolism. In the present study, we aimed to investigate the influence of RANKL/OPG allelic variations on the in vivo human gene expression of five genes, bone mineral density (BMD), and fracture incidence in Hungarian postmenopausal women.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1479-683X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
423-31
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pubmed:meshHeading |
pubmed-meshheading:19934266-Aged,
pubmed-meshheading:19934266-Alleles,
pubmed-meshheading:19934266-Bone Density,
pubmed-meshheading:19934266-Female,
pubmed-meshheading:19934266-Fractures, Bone,
pubmed-meshheading:19934266-Gene Expression,
pubmed-meshheading:19934266-Genetic Variation,
pubmed-meshheading:19934266-Haplotypes,
pubmed-meshheading:19934266-Humans,
pubmed-meshheading:19934266-Incidence,
pubmed-meshheading:19934266-Middle Aged,
pubmed-meshheading:19934266-Osteoprotegerin,
pubmed-meshheading:19934266-Polymorphism, Single Nucleotide,
pubmed-meshheading:19934266-Postmenopause,
pubmed-meshheading:19934266-RANK Ligand,
pubmed-meshheading:19934266-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
Allelic variations of RANKL/OPG signaling system are related to bone mineral density and in vivo gene expression.
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pubmed:affiliation |
1st Department of Internal Medicine, Semmelweis University, Korányi S u 2/a, Budapest H-1083, Hungary. takist@bel1.sote.hu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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