rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0022116,
umls-concept:C0034693,
umls-concept:C0078058,
umls-concept:C0185117,
umls-concept:C0205234,
umls-concept:C0205374,
umls-concept:C0221099,
umls-concept:C0290149,
umls-concept:C0302600,
umls-concept:C0332307,
umls-concept:C0441712,
umls-concept:C1171892,
umls-concept:C2911684
|
pubmed:issue |
3
|
pubmed:dateCreated |
2010-3-12
|
pubmed:abstractText |
The development of collateral vessels, which is important to prevent ischemic tissues from cell death, is impaired in patients with diabetes mellitus. The process is regulated by many positive and negative factors. The purpose of the study is to test the hypothesis that stroke patients with diabetes have angiogenesis deficiency and the possible mechanism is hyperglycemia attenuates neovascularization by downregulating proliferative properties of vascular endothelial growth factor (VEGF) and upregulating negative properties of angiostatin.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Mar
|
pubmed:issn |
1950-6007
|
pubmed:author |
|
pubmed:copyrightInfo |
Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.
|
pubmed:issnType |
Electronic
|
pubmed:volume |
64
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
208-13
|
pubmed:meshHeading |
pubmed-meshheading:19932587-Angiostatins,
pubmed-meshheading:19932587-Animals,
pubmed-meshheading:19932587-Antigens, CD31,
pubmed-meshheading:19932587-Blood Glucose,
pubmed-meshheading:19932587-Capillaries,
pubmed-meshheading:19932587-Diabetes Mellitus, Type 2,
pubmed-meshheading:19932587-Gene Expression Regulation,
pubmed-meshheading:19932587-Ischemic Attack, Transient,
pubmed-meshheading:19932587-Male,
pubmed-meshheading:19932587-Matrix Metalloproteinase 9,
pubmed-meshheading:19932587-Neovascularization, Physiologic,
pubmed-meshheading:19932587-Random Allocation,
pubmed-meshheading:19932587-Rats,
pubmed-meshheading:19932587-Rats, Mutant Strains,
pubmed-meshheading:19932587-Vascular Endothelial Growth Factor A
|
pubmed:year |
2010
|
pubmed:articleTitle |
The possible mechanism for impaired angiogenesis after transient focal ischemia in type 2 diabetic GK rats: different expressions of angiostatin and vascular endothelial growth factor.
|
pubmed:affiliation |
Department of Neurology, Affiliated Qianfoshan Hospital of Shandong University, 66 Jingshi Road, Ji'nan, Shandong province, China. dr_zhumeijia@126.com
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|