Linked Life Data

19932201

Source:http://linkedlifedata.com/resource/pubmed/id/19932201

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-3-30
pubmed:abstractText
In multicellular organisms apoptotic cells are rapidly and efficiently removed by professional or semi-professional phagocytes. The molecular mechanisms and the key players involved in this highly coordinate process, as well as its immunological outcome constitute a vividly expanding field of scientific interest. A plethora of studies provided a detailed understanding of the interaction site between the dying cell and the phagocyte, as well as to the current concept that apoptotic cell removal leads to a non- or anti-inflammatory response, whereas necrotic cell removal stimulates a pro-inflammatory reaction. In contrast, our current knowledge about the soluble factors released from apoptotic cells is rather limited, although meanwhile it is generally accepted that not only the dying cell itself but also the substances, which are liberated during cell death, contribute to the process of corpse clearance and the subsequent immune response. This review is intended to summarize the up-to-date knowledge about apoptotic cell-derived attraction signals, their function as phagocytic chemoattractants, their influence on the immune system, and the receptors, which are engaged in this scenario.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-0183
pubmed:author
pubmed:copyrightInfo
Copyright 2009. Published by Elsevier B.V.
pubmed:issnType
Electronic
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
425-30
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Scent of dying cells: the role of attraction signals in the clearance of apoptotic cells and its immunological consequences.
pubmed:affiliation
Institute for Clinical Immunology, Department for Internal Medicine 3, University Hospital Erlangen, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't